Tyrosine phosphorylation of synaptophysin in synaptic vesicle recycling
Tyrosine phosphorylation of synaptophysin in synaptic vesicle recycling
复制标题
DOI：
10.1042/bst0331350
复制
发表时间：
2005-12-01
影响因子：
3.9
通讯作者：
Cousin, MA
中科院分区：
文献类型：
--
作者：
Evans, GJO;Cousin, MA
积分SV（突触囊泡）蛋白突触素是鉴定出的第一个神经末端蛋白之一。然而，它在SV生命周期中的作用（如果有的话）仍然不确定。突触蛋白最突出的特征之一是其细胞质C末端很大程度上由酪氨酸残基引发的五肽重复。突触素在神经末端的酪氨酸激酶大量磷酸化，这表明这种磷酸化对其功能至关重要。这篇综述将涵盖突触素酪氨酸磷酸化的证据，以及该磷酸化如何控制其在SV生命周期中的功能。
The integral SV (synaptic vesicle) protein synaptophysin was one of the first nerve terminal proteins identified. However its role, if any, in the SV life cycle remains undetermined. one of the most prominent features of synaptophysin is that its cytoplasmic C-terminus largely consists of pentapeptide repeats initiated by a tyrosine residue. Synaptophysin is heavily phosphorylated by tyrosine kinases in the nerve terminal, suggesting that this phosphorylation is central to its function. This review will cover the evidence for tyrosine phosphorylation of synaptophysin and how this phosphorylation may control its function in the SV life cycle.