Responding to a 100-Year-Old Challenge from Fisher: A Biometrical Analysis of Adult Height in the NLSY Data Using Only Cousin Pairs.

Responding to a 100-Year-Old Challenge from Fisher: A Biometrical Analysis of Adult Height in the NLSY Data Using Only Cousin Pairs.
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回应费舍尔 100 年前的挑战:仅使用表兄弟对 NLSY 数据中成人身高的生物特征分析。

DOI:
10.1007/s10519-019-09967-6
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发表时间:
2019
期刊:
影响因子:
2.6
通讯作者:
vandenOord,EdwinJCG
vandenOord,EdwinJCG
中科院分区:
医学3区
文献类型:
--
作者:
Rodgers,JosephLee;Garrison,SMason;O'Keefe,Patrick;Bard,DavidE;Hunter,MichaelD;Beasley,WilliamH;vandenOord,EdwinJCG

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1918年,费舍尔提出,他的研究团队一直在发现夸大的表亲相关性。他还评论说,由于没有具有最小选择偏差的表亲样本,因此无法解决通货膨胀的原因,使这种通货膨胀成为一个尚待解决的挑战。在全国青年纵向调查(NLSY 79,NLSY 97和NLSY-儿童/青少年数据集)中,有数千对可用的表亲对。NLSYC/YA中的那些是近似地未经选择而获得的。在本文中,我们解决费舍尔的挑战,使用这些数据。此外,我们还评估了仅使用表兄弟对拟合ACE模型的可能性,包括全表兄弟,半表兄弟和四分之一表兄弟。要想在这样一个有限的亲属关系域中获得成功,需要一个可用且高度可靠的表型;我们在分析中使用了成年身高。结果提供了一个可能的答案费舍尔的挑战,并证明了潜在的使用表兄弟对在一个独立的分析(以及与其他生物统计学设计相结合)。
In 1918, Fisher suggested that his research team had consistently found inflated cousin correlations. He also commented that because a cousin sample with minimal selection bias was not available the cause of the inflation could not be addressed, leaving this inflation as a challenge still to be solved. In the National Longitudinal Survey of Youth (the NLSY79, the NLSY97, and the NLSY-Children/Young Adult datasets), there are thousands of available cousin pairs. Those in the NLSYC/YA are obtained approximately without selection. In this paper, we address Fisher’s challenge using these data. Further, we also evaluate the possibility of fitting ACE models using only cousin pairs, including full cousins, half-cousins, and quarter-cousins. To have any chance at success in such a restricted kinship domain requires an available and highly-reliable phenotype; we use adult height in our analysis. Results provide a possible answer to Fisher’s challenge, and demonstrate the potential for using cousin pairs in a stand-alone analysis (as well as in combination with other biometrical designs).
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