Routine Serologic Testing for Hepatitis C Virus Infection Should Be Instituted Among Dialysis Patients
Routine Serologic Testing for Hepatitis C Virus Infection Should Be Instituted Among Dialysis Patients
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应在透析患者中进行丙型肝炎病毒感染的常规血清学检测
DOI：
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发表时间：
2000
影响因子：
1.6
通讯作者：
BrianJ. G Pereira
中科院分区：
文献类型：
--
作者：
S. Natov;BrianJ. G Pereira
自克隆丙型肝炎病毒（HCV）以来，已为临床实践提供了一些用于检测丙型肝炎病毒感染的血清学和病毒学试验。这使得丙型肝炎病毒被认为是血液透析（HD）中心的主要健康危害。然而，肾脏病学界尚未对透析患者的HCV常规血清学检测提出明确的建议，因此对这种检测的效用仍然不清楚和存在分歧。本综述提供了支持在透析患者中建立HCV常规血清学检测的证据。结论：由于HD患者HCV感染的特殊特征，HCV血清学检测是明确诊断丙型肝炎的唯一手段，也是监测该人群感染发生率和流行程度的不可替代的工具。丙型肝炎病毒感染的血清学监测对于确定丙型肝炎病毒感染新病例与丙型肝炎病毒传播的潜在危险因素之间的关系至关重要，特别是医院内的危险因素，可以通过某种方式加以修改以防止病毒的进一步传播。从HCV常规血清学检测中收集的数据无疑将提高我们对透析人群中HCV流行病学的理解，并将为制定有效控制HCV感染的预防措施和感染控制策略提供坚实的基础。常规的HCV血清学检测对个体患者也有直接的好处，因为确定每个患者的HCV血清学状态对于优化患者护理非常重要。
Since the cloning of hepatitis C virus (HCV), a number of serologic and virologic tests for detecting infections with this virus have been made available for clinical practice. This led to the recognition of HCV as a major health hazard in hemodialysis (HD) centers. Yet the nephrology community has not been offered explicit recommendations about routine serologic testing for HCV of dialysis patients and consequently has remained unclear and divided about the utility of this testing. This review presents evidence in support of instituting routine serologic testing for HCV among dialysis patients. It concludes that because of the peculiar features of HCV infection in HD patients, serologic testing for HCV is the only means for unequivocal diagnosis of hepatitis C and an irreplaceable instrument for monitoring the incidence and the prevalence of the infection in this population. Serologic surveillance for HCV infection is crucial for identifying the association of new cases of HCV infection with potential risk factors for HCV transmission, particularly nosocomial, that can be modified in a way to prevent further dissemination of the virus. Data collected from routine serologic testing for HCV will undoubtedly improve our understanding of the epidemiology of HCV in the dialysis population and will provide a strong foundation for developing preventive measures and infection control strategies that are highly effective in controlling HCV infection. Routine serologic testing for HCV is also of direct benefit to the individual patient since establishing the HCV serologic status of each patient is important for optimizing patient care.
宿主细胞基因衍生表位 GOR 抗体在慢性丙型肝炎病毒感染中的意义。
影响因子：
25.7
作者：
Lau,JY;Davis,GL;Orito,E;Qian,KP;Mizokami,M
通讯作者：
Mizokami,M