Novel Fecobionics Defecatory Function Testing
Novel Fecobionics Defecatory Function Testing
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DOI：
10.14309/ctg.0000000000000108
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发表时间：
2019-12-01
影响因子：
3.6
通讯作者：
Futaba, Kaori
中科院分区：
文献类型：
--
作者：
Gregersen, Hans;Chen, Ssu-Chi;Futaba, Kaori
简介：排便是一个复杂的过程，很容易受到干扰。排便障碍可以通过专门的检查来诊断，包括肛门直肠测压（ARM）和球囊排出试验（BET）。最近，我们开发了一种名为Fecobionics的模拟凳子，它集成了几项测试，并评估了疏散过程中的压力，方向和弯曲。目的是评估的可行性和性能Fecobionics评估排便生理在正常subjects.METHODS：生理驱逐参数进行了评估，在干预性研究设计。10 cm长的Fecobionics探头在前后和袋内包含压力传感器和2个运动处理器单元。将袋在20名假定正常受试者（15名女性/5名男性）的直肠中扩张，直至出现排便冲动。还进行了ARM-BET。3例受试者使用+2分钟排空BET，1例受试者的大便失禁评分较高。因此，正常组包括16名受试者（13名女性/3名男性，年龄25 - 78岁）。Fecobionics排出压力特征表现为5个阶段，反映直肠压力、肛门松弛和肛门通过。前负荷-后负荷循环图显示顺时针收缩循环。BET和Fecobionics的排出持续时间分别为16 +/-2和23 +/-5秒（P> 0.2）。粪便仿生学和BET排出的持续时间相关（P <0.001）。排便过程中的Fecobionics弯曲的变化是40 +/-3 degrees.Discussion：Fecobionics生理条件下获得可靠的数据。ARM-BET和Fecobionics之间的可比变量一致，但其他变量不一致。研究表明，Fecobionics在评价关键排便参数方面是安全有效的。
INTRODUCTION: Defecation is a complex process that can be easily disturbed. Defecatory disorders may be diagnosed using specialized investigation, including anorectal manometry (ARM) and the balloon expulsion test (BET). Recently, we developed a simulated stool named Fecobionics that integrates several tests and assesses pressures, orientation, and bending during evacuation. The aim was to evaluate the feasibility and performance of Fecobionics for assessing defecatory physiology in normal subjects.METHODS: Physiological expulsion parameters were assessed in an interventional study design. The 10-cm-long Fecobionics probe contained pressure sensors at the front and rear and inside a bag and 2 motion processor units. The bag was distended in the rectum of 20 presumed normal subjects (15 female/5 male) until urge to defecate. ARM-BET was also performed. Three subjects used +2 minutes to evacuate BET, and 1 subject had a high fecal incontinence score. Therefore, the normal group consisted of 16 subjects (13 female/3 male aged 25-78 years).RESULTS: All subjects reported that Fecobionics evacuation was similar to normal defecation. Fecobionics expulsion pressure signatures demonstrated 5 phases, reflecting rectal pressure, anal relaxation, and anal passage. Preload-afterload loop diagrams demonstrated clockwise contraction cycles. The expulsion duration for BET and Fecobionics was 16 +/- 2 and 23 +/- 5 seconds (P> 0.2), respectively. The duration of the Fecobionics and BET expulsions was associated (P< 0.001). The change in bending of Fecobionics during defecation was 40 +/- 3 degrees.DISCUSSION: Fecobionics obtained reliable data under physiological conditions. Agreement was found for comparable variables between ARM-BET and Fecobionics but not for other variables. The study suggests that Fecobionics is safe and effective in evaluation of key defecatory parameters.