Geometric models to explore mechanisms of dynamic shape change in skeletal muscle.
Geometric models to explore mechanisms of dynamic shape change in skeletal muscle.
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DOI：
10.1098/rsos.172371
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发表时间：
2018-05
影响因子：
3.5
通讯作者：
Wakeling JM
中科院分区：
文献类型：
--
作者：
Dick TJM;Wakeling JM
骨骼肌收缩时会鼓起。这些三维（3D）动态形状变化通过改变肌肉运作的肌束速度范围在肌肉性能中起着重要作用。然而，传统的肌肉模型是一维的，不能完全解释体内形状的变化。在这项研究中，我们比较了内侧腓肠肌的行为在人类自行车通过传统的1D Hill型模型和通过将二维（2D）和3D几何约束结合到来自B的体内测量的模型预测的（束长度变化和旋转）。我们发现，1D模型预测的束长和羽状角与2D模型相似，模型，允许腱膜拉伸，并允许腱膜拉伸和可变形状的变化发生的3D模型。这表明，如果模型的目的是单独预测纤维束行为，那么传统的1D Hill型模型可能就足够了。然而，我们也警告说，1D模型在推断形状变化影响肌肉力学的机制方面的能力有限。为了阐明肌肉形状变化的机制，未来的努力应该旨在开发成像技术，能够表征整个肌肉的三维几何形状在体内主动收缩。
Skeletal muscle bulges when it contracts. These three-dimensional (3D) dynamic shape changes play an important role in muscle performance by altering the range of fascicle velocities over which a muscle operates. However traditional muscle models are one-dimensional (1D) and cannot fully explain in vivo shape changes. In this study we compared medial gastrocnemius behaviour during human cycling (fascicle length changes and rotations) predicted by a traditional 1D Hill-type model and by models that incorporate two-dimensional (2D) and 3D geometric constraints to in vivo measurements from B-mode ultrasound during a range of mechanical conditions ranging from 14 to 44 N m and 80 to 140 r.p.m. We found that a 1D model predicted fascicle lengths and pennation angles similar to a 2D model that allowed the aponeurosis to stretch, and to a 3D model that allowed for aponeurosis stretch and variable shape changes to occur. This suggests that if the intent of a model is to predict fascicle behaviour alone, then the traditional 1D Hill-type model may be sufficient. Yet, we also caution that 1D models are limited in their ability to infer the mechanisms by which shape changes influence muscle mechanics. To elucidate the mechanisms governing muscle shape change, future efforts should aim to develop imaging techniques able to characterize whole muscle 3D geometry in vivo during active contractions.
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影响因子：
2.4
作者：
Lee, Sabrina S. M.;Arnold, Allison S.;Miara, Maria de Boef;Biewener, Andrew A.;Wakeling, James M.
通讯作者：
Wakeling, James M.
影响因子：
2.8
作者：
Lichtwark, G. A.;Wilson, A. M.
通讯作者：
Wilson, A. M.
影响因子：
3.3
作者：
Bolsterlee, Bart;D'Souza, Arkiev;Herbert, Robert D.
通讯作者：
Herbert, Robert D.
影响因子：
3.3
作者：
Dick, Taylor J. M.;Wakeling, James M.
通讯作者：
Wakeling, James M.
影响因子：
64.8
作者：
HUXLEY, AF;NIEDERGERKE, R
通讯作者：
NIEDERGERKE, R