Underestimation of low-dose radiation in treatment planning of intensity-modulated radiotherapy
Underestimation of low-dose radiation in treatment planning of intensity-modulated radiotherapy
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DOI：
10.1016/j.ijrobp.2008.04.014
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发表时间：
2008-08-01
影响因子：
7
通讯作者：
Mohan, Radhe
中科院分区：
文献类型：
--
作者：
Jang, Si Young;Liu, H. Helen;Mohan, Radhe
Purpose: To investigate potential dose calculation errors in the low-dose regions and identify causes of such errors for intensity-modulated radiotherapy (IMRT).Methods and Materials: The IMRT treatment plans of 23 patients with lung cancer and mesothelioma were reviewed. Of these patients, 15 had severe pulmonary complications after radiotherapy. Two commercial treatment-planning systems (TPSs) and a Monte Carlo system were used to calculate and compare dose distributions and dose-volume parameters of the target volumes and critical structures. The effect of tissue heterogeneity, multi-leaf collimator (MLC) modeling, beam modeling, and other factors that could contribute to the differences in IMRT dose calculations were analyzed.Results: In the commercial TPS-generated IMRT plans, dose calculation errors primarily occurred in the low-dose regions of IMRT plans (
