Serum antibodies to periodontal pathogens and markers of systemic inflammation
Serum antibodies to periodontal pathogens and markers of systemic inflammation
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DOI：
10.1111/j.1600-051x.2005.00856.x
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发表时间：
2005-12-01
影响因子：
6.7
通讯作者：
Papapanou, PN
中科院分区：
文献类型：
--
作者：
Dye, BA;Choudhary, K;Papapanou, PN
我们研究了牙龈卟啉单胞菌和伴放线放线杆菌的血清抗体之间的关系，血浆纤维蛋白原和血清C-反应蛋白（CRP）在全国代表性sample.Data的2973参与者年龄40岁及以上的第三次全国健康与营养调查，第二阶段（1991-1994年）被使用。基于三种不同的假设，构建了三个逻辑回归模型，该模型调整了性别、种族、教育程度、糖尿病、吸烟、体重指数（BMI）和其他炎症状况：（A）无法获得牙齿/牙周数据;（B）了解牙齿数量，但不了解临床牙周状况;高纤维蛋白原（> 400 mg/dl）与牙龈卟啉单胞菌和A.伴放线菌抗体。在模型A [比值比（OR）1.63，95%置信区间（CI）1.15-2.32]、B（OR 1.69，95% CI 1.18-2.41）和C（OR 1.58，95% CI 1.12-2.23）中，高CRP（> 0.4 mg/dl）与高牙龈卟啉单胞菌抗体水平相关。在模型C中，高CRP与>= 3 mm的> 30%附着丧失程度相关（OR 1.58，95%CI 1.19-2.08）。抗A.在任何模型中，伴放线菌与高CRP水平无关。牙龈卟啉单胞菌的高血清滴度和牙周病的存在与高CRP水平独立相关。
We examined the relationship between serum antibodies against Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans, and plasma fibrinogen and serum C-reactive protein (CRP) in a nationally representative sample.Data on 2973 participants aged 40 years and older from the third National Health and Nutrition Examination Survey, second phase (1991-1994) were used. Three logistic regression models adjusted for gender, race, educational attainment, diabetes, cigarette smoking, body mass index (BMI), and other inflammatory conditions were constructed, based on three different assumptions: (A) no access to dental/periodontal data; (B) knowledge of number of teeth present but not of clinical periodontal status; and (C) knowledge of both dental and clinical periodontal status.High fibrinogen (> 400 mg/dl) was unrelated to P. gingivalis and A. actinomycetemcomitans antibodies in all models. High CRP (> 0.4 mg/dl) was related to high antibody levels to P. gingivalis in models A [odds ratios (OR) 1.63, 95% confidence intervals (CI) 1.15-2.32], B (OR 1.69, 95% CI 1.18-2.41), and C (OR 1.58, 95% CI 1.12-2.23). In model C, high CRP was related to > 30% extent of attachment loss of >= 3 mm (OR 1.58, 95% CI 1.19-2.08). Antibodies to A. actinomycetemcomitans were not associated with high CRP levels in any model.High serum titre to P. gingivalis and the presence of periodontal disease are independently related to high CRP levels.