70-year legacy of the Framingham Heart Study
70-year legacy of the Framingham Heart Study
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DOI：
10.1038/s41569-019-0202-5
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发表时间：
2019-11-01
影响因子：
49.6
通讯作者：
Vasan, Ramachandran S.
中科院分区：
文献类型：
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作者：
Andersson, Charlotte;Johnson, Andrew D.;Vasan, Ramachandran S.
FHS成立于1948年，旨在提高对美国冠心病（CHD）流行病学的了解。1961年，开创性的工作确定了冠心病的主要风险因素（高血压，高胆固醇水平和左心室肥大的心电图证据），后来形成了多变量10年和30年风险预测算法的基础。FHS队列现在包括三代参与者（n约15，000）和两个少数民族队列。FHS队列的表型分布密集，并定期随访检查和监测心血管和非心血管终点。对这些队列的亚临床疾病和生理特征进行了反复评估（使用超声心动图、动态心电图监测、运动负荷试验、心脏CT、心脏和大脑MRI、连续血管张力测定和加速度测定）。在过去的十年中，FHS队列经历了深度的“圆锥曲线”分析（包括全基因组测序，DNA甲基化分析，转录组学，高通量蛋白质组学和代谢组学以及微生物组学研究）。FHS是一项丰富的、纵向的、跨代的和深入的表型队列研究，持续关注最先进的流行病学方法和技术进步，以促进科学发现。
The Framingham Heart Study (FHS) was established in 1948 to improve understanding of the epidemiology of coronary heart disease (CHD) in the USA. In 1961, seminal work identified major risk factors for CHD (high blood pressure, high cholesterol levels and evidence on the electrocardiogram of left ventricular hypertrophy), which later formed the basis for multivariable 10-year and 30-year risk-prediction algorithms. The FHS cohorts now comprise three generations of participants (n approximate to 15,000) and two minority cohorts. The FHS cohorts are densely phenotyped, with recurring follow-up examinations and surveillance for cardiovascular and non-cardiovascular end points. Assessment of subclinical disease and physiological profiling of these cohorts (with the use of echocardiography, ambulatory electrocardiographic monitoring, exercise stress testing, cardiac CT, heart and brain MRI, serial vascular tonometry and accelerometry) have been performed repeatedly. Over the past decade, the FHS cohorts have undergone deep 'conics' profiling (including whole-genome sequencing, DNA methylation analysis, transcriptomics, high-throughput proteomics and metabolomics, and microbiome studies). The FHS is a rich, longitudinal, transgenerational and deeply phenotyped cohort study with a sustained focus on state-of-the-art epidemiological methods and technological advances to facilitate scientific discoveries.