Acarbose Decreases the Rheumatoid Arthritis Risk of Diabetic Patients and Attenuates the Incidence and Severity of Collagen-induced Arthritis in Mice.
Acarbose Decreases the Rheumatoid Arthritis Risk of Diabetic Patients and Attenuates the Incidence and Severity of Collagen-induced Arthritis in Mice.
复制标题
DOI：
10.1038/srep18288
复制
发表时间：
2015-12-18
影响因子：
4.6
通讯作者：
Lin CC
中科院分区：
文献类型：
--
作者：
Chen HH;Chen DY;Chao YH;Chen YM;Wu CL;Lai KL;Lin CH;Lin CC
已发现阿卡波糖可降低糖尿病患者的一些炎症参数。本研究旨在研究阿卡波糖对糖尿病（DM）患者类风湿性关节炎（RA）风险的影响以及对小鼠胶原诱导关节炎（CIA）的发生率和严重程度的影响。在一项全国性的病例对照研究中，我们确定了723例RA病例，并从所有新治疗的DM患者中选择了7，230例年龄、性别和RA诊断日期匹配的对照。我们发现阿卡波糖的使用剂量> 16，950 mg/年与较低的RA风险相关（比值比0.60; 95%CI，0.41-0.89）。在CIA小鼠研究中，相对于II型胶原（CII）免疫，从第-7天至第38天口服阿卡波糖。结果表明，阿卡波糖在500 mg/kg/d剂量下可降低关节炎的发生率和严重程度，并降低爪组织中促炎细胞因子（包括TNF-α、IL-6和IL-17）的表达。阿卡波糖进一步降低胶原反应性淋巴结细胞产生抗CII-IgG、IL-17和IFN-γ。这项工作表明，阿卡波糖的使用降低了糖尿病患者的RA风险和小鼠CIA的发病率。阿卡波糖还通过抗炎和免疫调节作用减轻CIA的严重程度。
Acarbose has been found to decrease some inflammatory parameters in diabetic patients. This study aimed to examine the influence of acarbose on rheumatoid arthritis (RA) risk in diabetes mellitus (DM) patients and on the incidence and severity of collagen-induced arthritis (CIA) in mice. In a nationwide, matched case–control study, we identified 723 incident RA cases and selected 7,230 age-, sex- and RA diagnosis date–matched controls from all newly treated DM patients. We found that use of acarbose at > 16,950 mg per year was associated with a lower RA risk (odds ratio 0.60; 95% CI, 0.41–0.89). In the CIA mouse study, acarbose was orally administered from days -7 to 38 relative to type II collagen (CII) immunization. The results revealed that acarbose at the dose of 500 mg/kg/day attenuated the incidence and severity of arthritis and the expression of proinflammatory cytokines, including TNF-α, IL-6 and IL-17 in the paw tissues. Acarbose further decreased the productions of anti-CII-IgG, IL-17 and IFN-γ by collagen-reactive lymph node cells. This work suggests that the use of acarbose decreased RA risk in DM patients and the incidence of CIA in mice. Acarbose also attenuated the severity of CIA via anti-inflammatory and immunomodulatory effects.