The effect of muscle loading on skeletal muscle regenerative potential: an update of current research findings relating to aging and neuromuscular pathology.
The effect of muscle loading on skeletal muscle regenerative potential: an update of current research findings relating to aging and neuromuscular pathology.
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DOI：
10.1097/phm.0b013e3181951fc5
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发表时间：
2009-02
影响因子：
3
通讯作者：
Huard J
中科院分区：
文献类型：
--
作者：
Ambrosio F;Kadi F;Lexell J;Fitzgerald GK;Boninger ML;Huard J
骨骼肌是一种动态组织，对环境刺激具有显著的持续响应能力。在其适应性反应中，骨骼肌在负荷或损伤或两者兼而有之后的再生能力被广泛研究。尽管大量的基础科学努力致力于更好地理解控制骨骼肌再生的潜在机制，但在用于治疗骨骼肌损伤和萎缩的临床方法中，影响相对较小。这篇综述文章的目的是概述卫星细胞对肌肉负荷的基本生物学反应，并将这些发现与衰老和神经肌肉病理学联系起来，供康复医学专家参考。
Skeletal muscle is a dynamic tissue with a remarkable ability to continuously respond to environmental stimuli. Among its adaptive responses is the widely investigated ability of skeletal muscle to regenerate after loading or injury or both. Although significant basic science efforts have been dedicated to better understand the underlying mechanism controlling skeletal muscle regeneration, there has been relatively little impact in the clinical approaches used to treat skeletal muscle injuries and wasting. The purpose of this review article is to provide an overview of the basic biology of satellite cell function in response to muscle loading and to relate these findings in the context of aging and neuromuscular pathology for the rehabilitation medicine specialist.