Bruch's Membrane Opening Minimum Rim Width and Retinal Nerve Fiber Layer Thickness in a Normal White Population: A Multicenter Study.
Bruch's Membrane Opening Minimum Rim Width and Retinal Nerve Fiber Layer Thickness in a Normal White Population: A Multicenter Study.
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DOI：
10.1016/j.ophtha.2015.06.001
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发表时间：
2015-09
期刊：
影响因子：
13.7
通讯作者：
Burgoyne CF
中科院分区：
文献类型：
--
作者：
Chauhan BC;Danthurebandara VM;Sharpe GP;Demirel S;Girkin CA;Mardin CY;Scheuerle AF;Burgoyne CF
传统的视盘边缘神经视网膜边缘测量缺乏坚实的解剖和几何基础。光学相干断层扫描（OCT）指数，布鲁赫膜开口最小边缘宽度（BMO-MRW），解决了这些缺陷，对青光眼具有更高的诊断准确性。我们对正常人群的BMO-MRW和乳头周围视网膜神经纤维层厚度（RNFLT）进行了表征。多中心横断面研究。正常的白人受试者。每个10岁组（20-90岁）大约相同数量的受试者被纳入5个中心。受试者眼部和视野检查正常。我们获得视神经头（24次径向扫描）和乳头周围视网膜（1次圆形扫描）的OCT图像。首先确定中央凹和BMO中心（FoBMO）之间相对于图像帧水平轴的角度，并获取所有扫描结果，并相对于该特定眼睛的FoBMO轴进行分析。分析BMO- mrw和RNFLT随年龄、扇形和BMO形状的变化。BMO-MRW和RNFLT的年龄相关性下降和受试者间变异性。246例受试者246只眼，中位年龄52.9岁（19.8 ~ 87.3岁）。FoBMO中位角度为- 6.7°（范围为2.5°至- 17.5°）。BMO主要呈垂直椭圆形，中位面积1.74 mm2（范围1.05 ~ 3.40 mm2）。FoBMO角度和BMO面积与年龄和轴向长度无关。全球平均BMO-MRW和RNFLT均随年龄的增长而下降，分别为- 1.34µm/年和- 0.21µm/年，相当于每10年寿命损失4.0%和2.1%。从区域上看，BMO-MRW的年龄相关性比RNFLT更强。总体平均BMO-MRW与RNFLT之间存在适度关系（r = 0.35），而部分关系从中度（r = 0.45，颞叶）到不存在（r = 0.01，颞叶）。健康受试者BMO-MRW的年龄相关性显著，BMO-MRW与RNFLT在年龄关系及相互之间存在显著差异。调整BMO-MRW和RNFLT的年龄和部门是重要的，以确保青光眼的最佳诊断。
Conventional optic disc margin-based neuroretinal rim measurements lack a solid anatomical and geometrical basis. An optical coherence tomography (OCT) index, Bruch’s membrane opening minimum rim width (BMO-MRW), addresses these deficiencies and has higher diagnostic accuracy for glaucoma. We characterized BMO-MRW and peripapillary retinal nerve fiber layer thickness (RNFLT) in a normal population. Multi-centred cross-sectional study. Normal White subjects. Approximately equal number of subjects in each decade group (20–90 years) was enrolled in 5 centers. Subjects had normal ocular and visual field examinations. We obtained OCT images of the optic nerve head (24 radial scans) and peripapillary retina (1 circular scan). The angle between the fovea and BMO center (FoBMO), relative to the horizontal axis of the image frame, was first determined and all scans were acquired and analyzed relative to this eye-specific FoBMO axis. Variation of BMO-MRW and RNFLT was analyzed with respect to age, sector and BMO shape. Age-related decline and between-subject variability in BMO-MRW and RNFLT. There were 246 eyes of 246 subjects with a median age of 52.9 (range, 19.8 to 87.3) years. The median FoBMO angle was −6.7° (range, 2.5° to −17.5°). BMO was predominantly vertically oval with a median area of 1.74 mm2 (range, 1.05 to 3.40 mm2). Neither FoBMO angle nor BMO area was associated with age or axial length. Both global mean BMO-MRW and RNFLT declined with age at a rate of −1.34 µm/y and −0.21 µm/y, equivalent to 4.0% and 2.1% loss per decade of life, respectively. Sectorally, the most rapid decrease occurred inferiorly and the least temporally, however, the age association was always stronger with BMO-MRW than with RNFLT. There was a modest relationship between mean global BMO-MRW and RNFLT (r = 0.35), while sectorally the relationship ranged from moderate (r = 0.45, inferotemporal) to non-existent (r = 0.01, temporal). There was significant age-related loss of BMO-MRW in healthy subjects and notable differences between BMO-MRW and RNFLT in their relationship with age and between each other. Adjusting BMO-MRW and RNFLT for age and sector is important in ensuring optimal diagnostics for glaucoma.