Extensive mitochondrial diversity within a single Amerindian tribe.
Extensive mitochondrial diversity within a single Amerindian tribe.
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单个美洲印第安部落内存在广泛的线粒体多样性。
DOI：
10.1073/pnas.88.19.8720
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发表时间：
1991
影响因子：
11.1
通讯作者：
Pääbo,S
中科院分区：
文献类型：
--
作者：
Ward,RH;Frazier,BL;Dew-Jager,K;Pääbo,S
对来自太平洋西北部的Nuu-Chah-Nulth美洲印第安部落的63个个体的线粒体控制区的360个核苷酸片段进行测序，发现存在由26个可变位置定义的28个谱系。这代表了一个小的当地人口的线粒体多样性的实质性水平。此外，这些Nuu-Chah-Nulth谱系之间的序列多样性大于在日本或撒哈拉以南非洲人等主要种族群体中观察到的线粒体序列多样性的60%。也有人观察到，大多数的Nuu-Chah-Nulth线粒体谱系落入系统发育簇。谱系群之间序列差异的大小表明，它们的起源早于人类进入美洲。由于一个美洲印第安部落可以包含如此广泛的分子多样性，因此没有必要假定在当代种族群体的形成过程中发生了重大的遗传瓶颈。特别是，这些数据并不支持在美洲的人口迁移过程中戏剧性的创始人效应的概念。
Sequencing of a 360-nucleotide segment of the mitochondrial control region for 63 individuals from an Amerindian tribe, the Nuu-Chah-Nulth of the Pacific Northwest, revealed the existence of 28 lineages defined by 26 variable positions. This represents a substantial level of mitochondrial diversity for a small local population. Furthermore, the sequence diversity among these Nuu-Chah-Nulth lineages is greater than 60% of the mitochondrial sequence diversity observed in major ethnic groups such as Japanese or sub-Saharan Africans. It was also observed that the majority of the mitochondrial lineages of the Nuu-Chah-Nulth fell into phylogenetic clusters. The magnitude of the sequence difference between the lineage clusters suggests that their origin predates the entry of humans into the Americas. Since a single Amerindian tribe can contain such extensive molecular diversity, it is unnecessary to presume that substantial genetic bottlenecks occurred during the formation of contemporary ethnic groups. In particular, these data do not support the concept of a dramatic founder effect during the peopling of the Americas.