MICROSCOPIC STUDIES OF HUMAN OLFACTORY EPITHELIA FOLLOWING TRAUMATIC ANOSMIA
MICROSCOPIC STUDIES OF HUMAN OLFACTORY EPITHELIA FOLLOWING TRAUMATIC ANOSMIA
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DOI：
10.1007/bf00453761
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发表时间：
1986-01-01
期刊：
影响因子：
--
通讯作者：
NAKANO, Y
中科院分区：
文献类型：
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作者：
HASEGAWA, S;YAMAGISHI, M;NAKANO, Y
我们设计了自己的仪器来获取人类嗅觉上皮的活组织标本。我们采集了两例颅脑外伤致嗅觉障碍患者的标本。用光学显微镜和透射电子显微镜观察嗅觉上皮细胞的形态变化。其特征性表现为嗅泡变性，尤其是纤毛消失，损伤小或早期改变。在损伤严重和损伤末期，嗅觉上皮表面未见嗅囊泡，嗅觉上皮细胞排列紊乱，细胞形态萎缩。我们的研究结果表明，创伤性嗅觉功能障碍中发生的上皮变性根据损伤的程度和损伤后的时间不同而不同。
We devised our own instrument for obtaining biopsy specimens of human olfactory epithelhium. We obtained specimens from two patients with anosmia caused by head trauma. The morphological changes in the olfactory epithelia were studied by light microscopy and transmission electron microscopy. With little damage or early stage of changes, the characteristic finding involved degeneration of the olfactory vesicles, especially with the disappearance of cilia. In the case of the great damage and the final stage of injury, no olfactory vesicles were found at the epithelial surface and the olfactory epithelia presented a disorganized cellular arrangement of cells with an atrophic appearance. Our findings indicate that the epithelial degeneration occurring in traumatic olfactory dysfunction varies according to the degree of damage incurred and the time lapse present from injury.