Treatment of Early Breast Cancer: A Report after Ten Years of a Clinical Trial
Treatment of Early Breast Cancer: A Report after Ten Years of a Clinical Trial
复制标题
早期乳腺癌的治疗：十年临床试验后的报告
作者：
H. Atkins;J. Hayward;D. Klugman;A. Wayte
一项对照临床试验已经进行，以比较乳腺癌根治术和扩大切除(扩大切除)在治疗早期乳腺癌中的作用。只有50岁及以上的患者被包括在内，370人在10年期间进入试验。术后均给予放射治疗。在有腋窝淋巴结受累的患者中，广泛切除的患者局部和远处复发的发生率显著高于根治性乳腺癌患者，而且这些患者的存活率显著低于根治性乳腺癌切除患者。在临床未累及淋巴结的患者中，尽管广泛切除的患者局部复发率显著较高，但远端复发的发生率并未增加，存活率与根治性乳腺癌切除患者相似。
A controlled clinical trial has been carried out to compare radical mastectomy with wide excision (extended tylectomy) in the treatment of early breast cancer. Only patients aged 50 and over were included and 370 entered the trial during a period of 10 years. Postoperative radiotherapy was given in each case. In patients with clinically involved axillary nodes there was a significantly higher incidence of local and distant recurrence in those having a wide excision, and the survival of these patients was significantly less than those who had a radical mastectomy. In patients with clinically uninvolved nodes, although there was a significantly higher incidence of local recurrence in those having a wide excision, there was no increased incidence of distant recurrence and the survival rate was similar to those having a radical mastectomy.