Vitamin B12 Derivatives Suitably Tailored for the Synthesis of Photolabile Conjugates.
Vitamin B12 Derivatives Suitably Tailored for the Synthesis of Photolabile Conjugates.
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适合合成光不稳定缀合物的维生素 B12 衍生物。
DOI：
10.1021/acs.orglett.1c00839
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发表时间：
2021
期刊：
影响因子：
5.2
通讯作者：
Gryko,Dorota
中科院分区：
文献类型：
--
作者：
Jackowska,Agnieszka;Gryko,Dorota
维生素B12结合物在生物科学中得到了广泛的研究。由于光提供了时空控制，我们决定开发一种制备维生素B12结合物的方法，该结合物在暴露于光时释放束缚分子。在此，我们报告了维生素B12衍生物具有光不稳定的连接适合共轭胺，叠氮化物，和炔。这种缀合物的潜在应用是广泛的，包括将药物、标记物和成像剂递送至其作用位置和时空释放。
Vitamin B12conjugates are broadly studied in biological sciences. As light offers spatiotemporal control, we decided to develop a method for the preparation of vitamin B12conjugates that release tethered molecules upon exposure to light. Herein, we report vitamin B12derivatives possessing a photolabile linker suitable for conjugation with amines, azides, and alkynes. The potential applications of such conjugates are broad and include the delivery of drugs, labels, and imaging agents to their place of action and spatiotemporal release.