Association of Arterial Stiffness and Electrocardiography-Determined Left Ventricular Hypertrophy with Left Ventricular Diastolic Dysfunction
Association of Arterial Stiffness and Electrocardiography-Determined Left Ventricular Hypertrophy with Left Ventricular Diastolic Dysfunction
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DOI：
10.1371/journal.pone.0049100
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发表时间：
2012-11-07
期刊：
影响因子：
3.7
通讯作者：
Sheu, Sheng-Hsiung
中科院分区：
文献类型：
--
作者：
Hsu, Po-Chao;Tsai, Wei-Chung;Sheu, Sheng-Hsiung
目的：动脉僵硬度升高与左室舒张功能障碍（LVDD）相关，但这种关联可能受左室（LV）功能的影响。左室肥厚（LVH）不仅是左室功能的重要决定因素，而且还与左室左室dd相关。本研究旨在比较以臂踝脉搏波速度（baPWV）和心电图（ECG）确定LVH划分的患者左室舒张功能，并评估baPWV升高和心电图确定LVH是否与LVDD独立相关。方法：本横断面研究纳入270例患者，根据baPWV中位数和伴有/不伴有ecg测定LVH分为4组。baPWV采用ABI-form装置测量。心电图测定LVH采用Sokolow-Lyon标准。LVDD定义为舒张受损，假异常，二尖瓣流入受限。1、2、3、4组分别为低baPWV且无ecg LVH、低baPWV但有ecg LVH、高baPWV但无ecg LVH、高baPWV且有ecg LVH。结果：1 ~ 4组早期舒张期二尖瓣速度（Ea）逐渐降低（p = 0.027）。第4组患者LVDD发生率最高（p < 0.05）
Objectives: Increased arterial stiffness is associated with left ventricular diastolic dysfunction (LVDD), but this association may be influenced by left ventricular (LV) performance. Left ventricular hypertrophy (LVH) is not only a significant determinant of LV performance, but is also correlated with LVDD. This study is designed to compare LV diastolic function among patients divided by brachial-ankle pulse wave velocity (baPWV) and electrocardiography (ECG)-determined LVH and to assess whether increased baPWV and ECG-determined LVH are independently associated with LVDD.Methods: This cross-sectional study enrolled 270 patients and classified them into four groups according to the median value of baPWV and with/without ECG-determined LVH. The baPWV was measured using an ABI-form device. ECG-determined LVH was defined by Sokolow-Lyon criterion. LVDD was defined as impaired relaxation, pseudonormal, and restrictive mitral inflow patterns. Groups 1, 2, 3, and 4 were patients with lower baPWV and without ECG-determined LVH, lower baPWV but with ECG-determined LVH, higher baPWV but without ECG-determined LVH, and higher baPWV and with ECG-determined LVH respectively.Results: Early diastolic mitral velocity (Ea) was gradually decreased from group 1 to group 4 (p = 0.027). Patients in group 4 had the highest prevalence of LVDD (all p