OX40 (CD134) and OX40L
OX40 (CD134) and OX40L
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DOI：
10.1007/978-0-387-89520-8_6
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发表时间：
2009-01-01
期刊：
影响因子：
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通讯作者：
Weinberg, Andrew D.
中科院分区：
文献类型：
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作者：
Gough, Michael J.;Weinberg, Andrew D.
OX40和OX40L之间的相互作用在抗原特异性T细胞的扩增和存活中起着重要作用。在抗原活化早期，OX40主要表达在T淋巴细胞上，而在急性炎症环境中，OX40L主要表达在活化的抗原提呈细胞和内皮细胞上。我们在这里讨论OX40L如何连接OX40导致T细胞存活率提高，以及局部炎症反应，这似乎对有效的T细胞介导的反应和慢性免疫病理都是至关重要的。我们描述了如何将阻断或模拟OX40-OX40L相互作用的干预措施应用于治疗自身免疫性疾病或增强抗肿瘤免疫反应。这些药物的临床相关特性强调了这种特殊的TNFSF-TNFSF在健康和疾病中的重要性。
The interaction between OX40 and OX40L plays an important role in antigen-specific T-cell expansion and survival. While OX40 is expressed predominantly on T-lymphocytes early after antigen activation, OX40L is expressed on activated antigen presenting cells and endothelial cells within acute inflammatory environments. We discuss here how ligation of OX40 by OX40L leads to enhanced T-cell survival, along with local inflammatory responses that appear critical for both effective T-cell mediated responses and chronic immune pathologies. We describe how interventions that block or mimic the OX40-OX40L interaction can be applied to treat autoimmune diseases or enhance anti-tumor immune responses. The clinically relevant properties of these agents emphasize the importance of this particular TNFSF-TNFSF in health and disease.