A MUTAGENIC METABOLITE PRODUCED BY FUSARIUM-MONILIFORME ISOLATED FROM LINXIAN COUNTY, CHINA
A MUTAGENIC METABOLITE PRODUCED BY FUSARIUM-MONILIFORME ISOLATED FROM LINXIAN COUNTY, CHINA
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DOI：
10.1093/carcin/6.6.903
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发表时间：
1985-01-01
期刊：
影响因子：
4.7
通讯作者：
LO, HZ
中科院分区：
文献类型：
--
作者：
CHENG, SJ;JIANG, YZ;LO, HZ
Fusarin C是近年来从食管癌高发区林县玉米中分离鉴定的一种真菌代谢产物。在S-9混合物存在下，镰孢菌素C显著增加鼠伤寒沙门氏菌TA 100中的回复突变体数量，并诱导V79细胞中的SCE [姐妹染色单体交换]、微核、染色体畸变和6-TG抗性突变体。在无S-9混合物存在下，镰刀菌素C对V79细胞的毒性作用更强。然而，在不添加S-9混合物的情况下，在使用的最大浓度下，镰孢菌素C对细胞未显示出任何显著的致突变或致染色体断裂作用。食用受F.对念珠状癌与食管癌的病因进行了讨论。
Fusarin C, a fungal metabolite, was recently isolated and identified from corn meal inoculated with Fusarium moniliforme which was one of the most common fungi associated with corn in Linxian county, a high-incidence area of esophageal cancer. In the presence of S-9 mix, fusarin C significantly increased the number of revertants in Salmonella typhimurium TA 100 and induced SCE [sister chromatid exchange], micronuclei, chromosome aberrations and 6-TG resistant mutants in V79 cells. The toxic action of fusarin C on V79 cells was much stronger in the absence of S-9 mix. However, fusarin C did not show, at the largest concentration used, any significant mutagenic or clastogenic effect on the cells without the addition of S-9 mix. The possible relationship between the consumption of corn contaminated with F. moniliforme and the cause of esophageal cancer was discussed.