Oral Cancer: Integration of Studies for Diagnostic and Therapeutic Precision.
Oral Cancer: Integration of Studies for Diagnostic and Therapeutic Precision.
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DOI：
10.1177/0022034519877388
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发表时间：
2019-11-01
影响因子：
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通讯作者：
Gutkind, J S
中科院分区：
文献类型：
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作者：
D'Silva, N J;Gutkind, J S
头颈癌是世界上最常见的10种癌症之一，包括口腔癌、下咽癌、喉癌、鼻咽癌和口咽癌。至少90%的头颈部癌症是鳞状细胞癌（SCCs）。本综述讨论了在口腔癌的背景下实现诊断和治疗精度的临床和机制研究的整合。具体而言，基于最近的机制研究，随后的一项研究重新评估了口腔SCC患者神经周围侵袭的现行诊断标准，表明总生存率可能与神经肿瘤距离有关；在一小群患者中验证这项研究的结果可能会导致口腔SCC患者治疗选择的个性化方法。此外，对SCC关键通路的描述揭示了新的治疗靶点，可用于制定个性化治疗策略以实现长期缓解。
Head and neck cancers are among the 10 most common cancers in the world and include cancers of the oral cavity, hypopharynx, larynx, nasopharynx, and oropharynx. At least 90% of head and neck cancers are squamous cell carcinomas (SCCs). This summary discusses the integration of clinical and mechanistic studies in achieving diagnostic and therapeutic precision in the context of oral cancer. Specifically, based on recent mechanistic studies, a subsequent study reevaluated current diagnostic criteria of perineural invasion in patients with oral cavity SCC showing that overall survival could be associated with nerve-tumor distance; validation of the findings of this study from a small group of patients could lead to a personalized approach to treatment selection in patients with oral cavity SCC. Moreover, delineation of key pathways in SCC revealed novel treatment targets that can be exploited to develop personalized treatment strategies to achieve long-term remission.