A study toward a total synthesis of fostriecin
A study toward a total synthesis of fostriecin
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DOI：
10.1016/s0040-4039(02)00403-3
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发表时间：
2002-04-08
影响因子：
1.8
通讯作者：
Kobayashi, Y
中科院分区：
文献类型：
--
作者：
Kiyotsuka, Y;Igarashi, J;Kobayashi, Y
为了合成磷三菌素的主要 C(3)-C(12) 部分，通过几种类型的交叉偶联反应制备了几种二烯 5a-f 的不对称二羟基化。 vas 研究，因此提供了对 C(5) 和 C(l 1) 处羟基的高度依赖性。 5d时获得最佳区域选择性，生成二醇23。随后将其转化为高级中间体26。(C)2002 Elsevier Science Ltd.保留所有权利。
In order to synthesize the major C(3)-C(12) part of fostriecin, asymmetric dihydroxylation of several dienes 5a-f, prepared by cross-coupling reactions of several types. vas studied, thus providing high dependency on the hydroxyl groups at C(5) and C(l 1). The best regioselectivity was obtained with 5d to produce diol 23. which was later transformed into the advanced intermediate 26. (C) 2002 Elsevier Science Ltd. All rights reserved.