9-(DIALKYLAMINOALKYL)-ISOALLOXAZINES
9-(DIALKYLAMINOALKYL)-ISOALLOXAZINES
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DOI：
10.1021/ja01196a016
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发表时间：
1947-01-01
影响因子：
15
通讯作者：
SPOERRI, PE
中科院分区：
文献类型：
--
作者：
KIPNIS, F;WEINER, N;SPOERRI, PE
本文介绍了一种实用的1，2，3，4-四氢喹喔啉单烷基化反应方法。这涉及用苯磺酰氯封闭一个氮，并在另一个氮上烷基化，然后水解除去苯磺酸。由此可以从母体喹喔啉以42-58%的总收率获得简单的单烷基衍生物。2.已经制备了几个系列，包括先前未描述的三十种化合物。
A practical procedure has beendeveloped for the monoalkylation of 1, 2, 3, 4-tetrahydroquinoxaline. This involves blocking one nitrogen with benzenesulfonyl chloride and alkylating at the other nitrogen followed by hydrolytic removal of benzenesulfonic acid. Simple monoalkyl derivatives may thereby be obtained in over-all yields of 42-58% from the parent quinoxaline. 2. Several series, comprising thirty compounds not previously described, have been prepared.