Fabrication of highly sensitive and uniform Ag/PS/PDMS SERS substrate and its application for in-situ detection
Fabrication of highly sensitive and uniform Ag/PS/PDMS SERS substrate and its application for in-situ detection
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DOI：
10.1088/1361-6528/ac59e9
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发表时间：
2022-03
期刊：
影响因子：
3.5
通讯作者：
Guangming Xu;Xilong Shen;Lei Zhang;Jie Tang;Chuan He;Ziqiang Zhou;Tian Xu;Meifeng Xu;Yonglong Jin;Chaonan Wang
中科院分区：
文献类型：
--
作者：
Guangming Xu;Xilong Shen;Lei Zhang;Jie Tang;Chuan He;Ziqiang Zhou;Tian Xu;Meifeng Xu;Yonglong Jin;Chaonan Wang
在这项研究中，我们开发了一个灵活的和透明的银/聚苯乙烯/聚二甲基硅氧烷（Ag/PS/PDMS）基板与高密度的热点和令人满意的均匀性，使用成本效益的方法。通过模板引导的自组装，PS珠在PDMS上规则地排列在纳米碗的正方形阵列中，其表面结构是从商业互补金属氧化物半导体芯片转移的。通过氮等离子体处理在PS珠表面引入粗糙度，然后溅射银，产生许多热点。PS微珠表面的不同粗糙度对Ag/PS/PDMS基底的形貌有很大影响。在等离子体刻蚀时间为5 min时，薄膜表面形成了一种类似于肉球的表面结构，并通过扫描电镜分析了其生长机理。以结晶紫为拉曼报告剂，制备的肉丸状Ag/PS/PDMS基底具有较高的灵敏度和较好的均匀性，增强因子为2.7 × 107，相对标准偏差为5.04%。黄瓜表面的福美双的浓度低于最大残留限量可以很容易地被检测到原位的建议基板，展示了其巨大的潜力，原位食品安全分析。
In this study, we developed a flexible and transparent silver/polystyrene/polydimethylsiloxane (Ag/PS/PDMS) substrate with both high density of hot spots and satisfactory uniformity using a cost-effective approach. Via template-guided self-assembly, PS beads were arranged regularly in nanobowls of a square array on PDMS, whose surface structure was transferred from a commercial complementary metal oxide semiconductor chip. Roughness was introduced onto the PS bead surface by nitrogen plasma treatment, followed by sputtering of Ag which generated many hot spots. Differential roughness on the PS bead surface greatly influenced the morphology of the Ag/PS/PDMS substrate. A meat-ball like surface structure was formed with a plasma etching time of 5 min, whose growth mechanism was proposed based on the scanning electron microscope analysis. The high sensitivity and desirable uniformity of the meat-ball like Ag/PS/PDMS substrate were demonstrated by using crystal violet as a Raman reporter, exhibiting an enhancement factor of 2.7 × 107 and a relative standard deviation of 5.04%. Thiram of a lower concentration than the maximum residue limit on the cucumber surface could easily be detected in situ by the proposed substrate, demonstrating its great potential for in-situ food safety analysis.