Oncologic impact of micrometastases or isolated tumor cells in sentinel lymph nodes of patients with endometrial cancer: a meta-analysis.
Oncologic impact of micrometastases or isolated tumor cells in sentinel lymph nodes of patients with endometrial cancer: a meta-analysis.
复制标题
DOI：
10.1007/s12094-019-02249-x
复制
发表时间：
2020-08
期刊：
影响因子：
--
通讯作者：
Gil-Moreno A
中科院分区：
文献类型：
--
作者：
Gómez-Hidalgo NR;Ramirez PT;Ngo B;Pérez-Hoyos S;Coreas N;Sanchez-Iglesias JL;Cabrera S;Franco S;Benavente AP;Gil-Moreno A
关于子宫内膜癌患者前哨淋巴结中发现的微转移（MIC）和孤立肿瘤细胞（ITC）的影响，目前还存在知识空白。在此，我们对已发表的文献进行荟萃分析，分析淋巴管定位后MIC和ITC的发生率，并确定术后管理的趋势。使用以下术语对Medline和PubMed进行文献检索：微转移、孤立肿瘤细胞、子宫内膜癌和前哨淋巴结。入选标准为：1999年1月至2019年6月期间发表的英文手稿、回顾性或前瞻性研究。我们删除了未明确微转移或孤立肿瘤细胞信息的前哨淋巴结定位的文章、非英语文章、无肿瘤学结局数据的文章以及10例或以下病例的文章，共回顾了45篇文章，8篇研究符合纳入标准。我们发现MIC/ITC患者总数为286例（分别为187例和99例）。在前哨淋巴结中检测到MIC/ITC的72%的患者接受了辅助治疗。MIC/ITCs组复发的相对风险为1.34（1.07，1.67），高于阴性组，即使给予辅助治疗。我们注意到，即使在接受辅助治疗后，低转移患者复发的相对风险也会增加。是否需要辅助治疗仍然是一个争论的话题，因为还有其他子宫因素与预后有关。多机构肿瘤登记可能有助于阐明这一重要问题。
There is a gap in knowledge regarding the impact of micrometastases (MIC) and isolated tumor cells (ITCs) found in the sentinel lymph nodes of patients with endometrial cancer. Here, we present a meta-analysis of the published literature on the rate of MIC and ITCs after lymphatic mapping and determine trends in postoperative management. Literature search of Medline and PubMed was done using the terms: micrometastases, isolated tumor cells, endometrial cancer, and sentinel lymph node. Inclusion criteria were: English-language manuscripts, retrospectives, or prospective studies published between January 1999 and June 2019. We removed manuscripts on sentinel node mapping that did not specify information on micrometastases or isolated tumor cells, non-English-language articles, no data about oncologic outcomes, and articles limited to ten cases or less. A total of 45 manuscripts were reviewed, and 8 studies met inclusion criteria. We found that the total number of patients with MIC/ITCs was 286 (187 and 99, respectively). The 72% of patients detected with MIC/ITCs in sentinel nodes received adjuvant therapies. The MIC/ITCs group has a higher relative risk of recurrence of 1.34 (1.07, 1.67) than the negative group, even if the adjuvant therapy was given. We noted that there is an increased relative risk of recurrence in patients with low-volume metastases, even after receiving adjuvant therapy. Whether adjuvant therapy is indicated remains a topic of debate because there are other uterine factors implicated in the prognosis. Multi-institutional tumor registries may help shed light on this important question.
登录
查看更多内容
乳腺癌中的神秘腋窝淋巴结转移：它们的检测和预后意义。
影响因子：
8.8
作者：
McGuckin, M A;Cummings, M C;Walsh, M D;Hohn, B G;Bennett, I C;Wright, R G
通讯作者：
Wright, R G
影响因子：
1.6
作者：
Abu-Rustum, Nadeem R.
通讯作者：
Abu-Rustum, Nadeem R.
影响因子：
4.3
作者：
Hakim, Amy A;Terada, Keith Y
通讯作者：
Terada, Keith Y
影响因子：
2.5
作者：
Piedimonte, Sabrina;Richer, Lara;Zeng, Xing Ziggy
通讯作者：
Zeng, Xing Ziggy
影响因子：
50.5
作者：
Barranger, E;Cortez, A;Callard, P
通讯作者：
Callard, P