Biomarkers for Myocarditis and Inflammatory Cardiomyopathy.
Biomarkers for Myocarditis and Inflammatory Cardiomyopathy.
复制标题
DOI：
10.1007/s11897-022-00569-8
复制
发表时间：
2022-10
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
心肌炎是一种由心脏炎症引起的疾病，可发展为扩张性心肌病、心力衰竭，并最终导致许多患者死亡。几种病因与心肌炎的发展有关，包括自身免疫性、药物性、感染性和其他。所有原因导致炎症，导致心肌损伤，然后是重塑和纤维化。本文综述了心肌炎生物标志物的最新发现，并重点介绍了最有希望的候选生物标志物。目前诊断心肌炎的方法，包括影像学和心内膜活检，都是侵入性的，昂贵的，而且往往不够早，无法影响进展。研究人员正在寻找具有成本效益、准确性和预后信息的心肌炎生物标志物。这些生物标志物将允许早期筛查心肌炎，以及早期治疗，并更好地了解特定患者的病程。使用生物标记物进行心肌炎的早期诊断可能允许及时治疗以改善患者的预后。
Myocarditis is a disease caused by inflammation of the heart that can progress to dilated cardiomyopathy, heart failure, and eventually death in many patients. Several etiologies are implicated in the development of myocarditis including autoimmune, drug-induced, infectious, and others. All causes lead to inflammation which causes damage to the myocardium followed by remodeling and fibrosis. This review aims to summarize recent findings in biomarkers for myocarditis and highlight the most promising candidates. Current methods of diagnosing myocarditis, including imaging and endomyocardial biopsy, are invasive, expensive, and often not done early enough to affect progression. Research is being done to find biomarkers of myocarditis that are cost-effective, accurate, and prognostically informative. These biomarkers would allow for earlier screening for myocarditis, as well as earlier treatment, and a better understanding of the disease course for specific patients. Early diagnosis of myocarditis with biomarkers may allow for prompt treatment to improve outcomes in patients.