Social isolation induces behavioral and neuroendocrine disturbances relevant to depression in female and male prairie voles
Social isolation induces behavioral and neuroendocrine disturbances relevant to depression in female and male prairie voles
复制标题
DOI：
10.1016/j.psyneuen.2007.07.004
复制
发表时间：
2007-09-01
影响因子：
3.7
通讯作者：
Carter, C. Sue
中科院分区：
文献类型：
--
作者：
Grippo, Angela J.;Gerena, Davida;Carter, C. Sue
支持性的社会互动可能对压力源和某些精神和身体疾病有保护作用，而社会隔离可能是一个强大的压力源。草原田鼠是一夫一妻制的社会性啮齿类动物，它们模仿了人类表现出的一些行为和生理特征，包括对社会的敏感性。隔离。在4周的社交活动后，对成年雌性草原田鼠和雄性草原田鼠进行了神经内分泌和行为参数的测量，这些参数与压力和抑郁有关。隔离vs成对住房。实验1，催产素免疫反应细胞。下丘脑室旁核（PVN）密度较高，血浆催产素在离体雌性中升高，但在配偶中没有升高。在试验2中，蔗糖的摄入量，作为一种操作。在隔离4周后，男性和女性对快感的定义都有所降低。然后，动物接受常驻入侵者测试，并在10分钟后处死以分析循环激素和肽，或在2小时后处死以检测神经激活，通过PVN细胞中对催产素或促肾上腺皮质激素释放因子（CRF）免疫反应的c-Fos表达来指示。与配对动物相比，隔离雌性小鼠血浆催产素、促肾上腺皮质激素和皮质酮水平升高，而隔离雄性小鼠血浆催产素水平升高。在分离的雌性中，c-Fos和催产素或c-Fos和CRF双重标记的细胞比例升高，在分离的雄性中，c-Fos和催产素双重标记的细胞比例升高。这些发现表明，社会隔离诱导雄性和雌性草原田鼠的行为和神经内分泌反应与抑郁有关，尽管雌性草原田鼠的神经内分泌反应可能对孤立特别敏感。(C) 2007 Elsevier Ltd.版权所有。
Supportive social interactions may be protective against stressors and certain mental and physical illness, while social isolation may be a powerful stressor. Prairie voles are socialty monogamous rodents that model some of the behavioral and physiological traits displayed by humans, including sensitivity to social. isolation. Neuroendocrine and behavioral parameters, selected for their relevance to stress and depression, were measured in adult female and mate prairie voles following 4 weeks of social. isolation versus paired housing. In Experiment 1, oxytocin-immunoreactive cell. density was higher in the hypothalamic paraventricular nucleus (PVN) and plasma oxytocin was elevated in isolated females, but not in mates. In Experiment 2, sucrose intake, used as an operational. definition of hedonia, was reduced in both sexes following 4 weeks of isolation. Animals then received a resident-intruder test, and were sacrificed either 10min later for the analysis of circulating hormones and peptides, or 2h later to examine neural activation, indexed by c-Fos expression in PVN cells immunoreactive for oxytocin or corticotropin-releasing factor (CRF). Compared to paired animals, plasma oxytocin, ACTH and corticosterone were elevated in isolated females and plasma oxytocin was elevated in isolated mates, following the resident-intruder test. The proportion of cells double-labeled for c-Fos and oxytocin or c-Fos and CRF was elevated in isolated females, and the proportion of cells double-labeled for c-Fos and oxytocin was elevated in isolated mates following this test. These findings suggest that social isolation induces behavioral and neuroendocrine responses relevant to depression in mate and female prairie voles, although neuroendocrine responses in females may be especially sensitive to isolation. (C) 2007 Elsevier Ltd. All rights reserved.