Analysis of prognostic factors and 5-year survival rate in patients with hepatocellular carcinoma: a single-center experience.
Analysis of prognostic factors and 5-year survival rate in patients with hepatocellular carcinoma: a single-center experience.
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DOI：
10.3350/kjhep.2012.18.1.48
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发表时间：
2012-03-01
期刊：
影响因子：
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通讯作者：
Song, Il Han
中科院分区：
文献类型：
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作者：
Lee, Sang Seok;Shin, Hyun Sung;Song, Il Han
背景/目的：肝细胞癌（HCC）是韩国第三大常见癌症，预后非常差。然而，只有少数研究对在给定时间内连续诊断和治疗的所有患者进行了全面的生存相关分析。本研究的目的是确定HCC patients.METHODS之间的5年生存率及其预后因素：在2000年1月至2003年12月期间连续诊断为HCC的257例患者，随访至死亡或至2008年12月。我们根据患者的临床特征、肿瘤分期和治疗方式分析其生存结局，并确定影响生存的独立预后因素。随访期间，223例患者（86.8%）死亡，总中位生存期为10.8个月; 1年、3年和5年生存率分别为44.4%、21.0%和12.1%。肿瘤淋巴结转移（TNM）I、II期及Child-Pugh分级A、B级患者手术切除的疗效明显优于其他治疗方式（P
BACKGROUND/AIMS: Hepatocellular carcinoma (HCC), which is the third most common cancer in Korea, has a very poor prognosis. However, only a few studies have performed a comprehensive survival-related analysis in all patients who were consecutively diagnosed and treated over a given period of time. The aim of this study was to determine the 5-year survival rate and its prognostic factors among HCC patients.METHODS: In total, 257 patients who were consecutively diagnosed with HCC between January 2000 and December 2003 were followed until death or until December 2008. We analyzed their survival outcomes according to their clinical characteristics, tumor staging, and treatment modalities, and determined the independent prognostic factors affecting survival.RESULTS: The patients were aged 59±10 years (mean±SD). During the follow-up period, 223 patients (86.8%) died and the overall median survival was 10.8 months; the 1-, 3-, and 5-year survival rates were 44.4%, 21.0%, and 12.1%, respectively. The outcomes in patients with tumor node metastasis (TNM) stage I or II and Child-Pugh class A or B were significantly better with surgical resection than with other treatment modalities (P