Antimalarial Drug Resistance: Literature Review and Activities and Findings of the ICEMR Network.
Antimalarial Drug Resistance: Literature Review and Activities and Findings of the ICEMR Network.
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DOI：
10.4269/ajtmh.15-0007
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发表时间：
2015-09
期刊：
影响因子：
--
通讯作者：
Rosenthal PJ
中科院分区：
文献类型：
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作者：
Cui L;Mharakurwa S;Ndiaye D;Rathod PK;Rosenthal PJ
抗疟疾药物是控制和消除疟疾的关键工具。最近全球疟疾负担的减少可能部分是由于部署了以青蒿素为基础的联合疗法。因此，耐青蒿素寄生虫在东南亚的出现和潜在传播以及对青蒿素伙伴药物敏感性的变化引起了人们的关注。认识到这一紧迫威胁，国际疟疾研究英才中心(ICEMR)正在密切监测抗疟疾药物的疗效，并研究产生耐药性的机制。在全球ICEMR网络的多个哨点，研究活动包括跟踪抗疟疾药物有效性的临床研究，测量寄生虫分离株药物敏感性的体外/体外试验，以及耐药介导型寄生虫的多态特征。综上所述，这些努力提供了对抗疟疾治疗效果的日益全面的评估，并使我们能够预测耐药性的出现，并指导当地的抗疟疾药物政策。在这里，我们简要回顾世界范围内的抗疟疾耐药性问题，总结ICEMR与耐药性相关的研究活动，并评估ICEMR计划的全球影响。
Antimalarial drugs are key tools for the control and elimination of malaria. Recent decreases in the global malaria burden are likely due, in part, to the deployment of artemisinin-based combination therapies. Therefore, the emergence and potential spread of artemisinin-resistant parasites in southeast Asia and changes in sensitivities to artemisinin partner drugs have raised concerns. In recognition of this urgent threat, the International Centers of Excellence for Malaria Research (ICEMRs) are closely monitoring antimalarial drug efficacy and studying the mechanisms underlying drug resistance. At multiple sentinel sites of the global ICEMR network, research activities include clinical studies to track the efficacies of antimalarial drugs, ex vivo/in vitro assays to measure drug susceptibilities of parasite isolates, and characterization of resistance-mediating parasite polymorphisms. Taken together, these efforts offer an increasingly comprehensive assessment of the efficacies of antimalarial therapies, and enable us to predict the emergence of drug resistance and to guide local antimalarial drug policies. Here we briefly review worldwide antimalarial drug resistance concerns, summarize research activities of the ICEMRs related to drug resistance, and assess the global impacts of the ICEMR programs.