Differential regulation of the consummatory, motivational and anticipatory aspects of feeding behavior by dopaminergic and opioidergic drugs
Differential regulation of the consummatory, motivational and anticipatory aspects of feeding behavior by dopaminergic and opioidergic drugs
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DOI：
10.1038/sj.npp.1300908
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发表时间：
2006-07-01
影响因子：
7.6
通讯作者：
Cador, M
中科院分区：
文献类型：
--
作者：
Barbano, MF;Cador, M
摄食行为的各个方面(如摄食、动机和预期)受体内平衡和享乐系统的调节，并受多巴胺能和阿片类大脑系统的调节。在这里，我们研究了阿片类药物和多巴胺能神经传递对摄食行为的这些方面的调节，同时考虑了食物的适口性和体内平衡状态。在测量喂养的不同方面的行为范式中，在注射不同剂量的阿片受体拮抗剂纳洛酮或多巴胺能受体拮抗剂氟苯硫醇后，食物适口性不同的食物被提供给食物饱足或食物受限的大鼠。纳洛酮以剂量依赖的方式减少饱足大鼠的摄食量，使其能够获得美味的食物，而不改变食物限制大鼠的摄食量。氟苯硫醇对食物摄入量没有任何影响。至于动机，这是在一条笔直的巷子里测试的，纳洛酮只在吃饱了食物的大鼠身上延长了到达食物的潜伏期。氟苯硫醇不改变任何组的潜伏期。对重复食物呈现的条件性运动活动，这是一种预期的衡量标准，仅在食物限制的大鼠中表达。纳洛酮没有改变预期活性，而氟苯硫醇仅在食物受限的大鼠中降低了预期活性。这些结果强化了阿片系统通过调节食物的适口性来调节进食的观点。多巴胺能系统似乎对与动机相关的刺激相关的预期活动的调节更为重要。
Various aspects of feeding behavior (eg consumption, motivation and anticipation) are regulated by homeostatic and hedonic systems, and are modulated by dopaminergic and opioid brain systems. Here, we have studied the modulation of these aspects of feeding behavior by opioid and dopaminergic neurotransmission while taking into account food palatability and homeostatic state. Foods that varied in palatability were presented to either food sated or food restricted rats following injections of different doses of naloxone, an opioid receptor antagonist, or flupenthixol, a dopaminergic receptor antagonist, in behavioral paradigms that measured different aspects of feeding. Naloxone decreased food intake in a dose-dependent manner in sated rats given access to palatable food, without modifying food intake in food restricted rats. Flupenthixol did not have any effect on food intake. With regard to motivation, which was tested in a straight alley, naloxone increased the latency to reach the food only in sated rats presented with palatable food. Flupenthixol did not modify the latency of any group. Conditioned locomotor activity to repeated food presentation, a measure of anticipation, is expressed only in food restricted rats. Naloxone did not modify anticipatory activity, whereas flupenthixol decreased it only in food restricted rats presented with palatable food. These results reinforce the idea that the opioid system regulates feeding through the modulation of the perceived palatability of food. The dopaminergic system seems to be more important for the regulation of anticipatory activity related to motivationally relevant stimuli.