Rapid Peripheral Nerve Imaging by Fluorescent Polymer Dots for Minimizing the Risk of Intraoperative Nerve Injury
Rapid Peripheral Nerve Imaging by Fluorescent Polymer Dots for Minimizing the Risk of Intraoperative Nerve Injury
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DOI：
10.1002/anse.202300042
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发表时间：
2023-09-08
期刊：
影响因子：
--
通讯作者：
Xiong，Liqin
中科院分区：
文献类型：
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作者：
Zhang，Juxiang;Lu，Shuting;Xiong，Liqin
医源性神经损伤是手术并发症的重要原因。我们专注于通过高荧光聚合物点（Pdots）和体内光学成像仪器来改善神经的术中可视化。 所制备的Pdot具有良好的生物相容性和荧光稳定性，且制备简单。Pdot可以通过简单的直接给药方法和过程快速成像周围神经，在周围组织中的非特异性吸收低。此外，Pdot不侵入神经细胞，而是稳定地结合在神经膜结构中。本研究验证了荧光Pdot具有良好的神经成像能力，可用于周围神经的术中可视化。
Iatrogenic nerve injury is an important cause of surgical complications. We focused on improving intraoperative visualization of nerves through highly fluorescent polymer dots (Pdots) and in vivo optical imaging instrumentation. The prepared Pdots have good biocompatibility, fluorescence stability, and simple preparation. Peripheral nerves can be imaged quickly with Pdots through a simple direct administration method and process, low non‐specific absorption in the surrounding tissues. Moreover, the Pdots does not invade nerve cells but binds stably in the neural membrane structure. This study verifies that fluorescent Pdots have excellent neuroimaging capabilities and can be used for intraoperative visualization of peripheral nerves.