Conductive adhesive self-healing nanocomposite hydrogel wound dressing for photothermal therapy of infected full-thickness skin wounds
Conductive adhesive self-healing nanocomposite hydrogel wound dressing for photothermal therapy of infected full-thickness skin wounds
复制标题
导电胶自愈纳米复合水凝胶伤口敷料用于感染全层皮肤伤口的光热治疗
DOI：
10.1016/j.cej.2020.124888
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发表时间：
2020-08-15
影响因子：
15.1
通讯作者：
Guo, Baolin
中科院分区：
文献类型：
--
作者：
He, Jiahui;Shi, Mengting;Guo, Baolin
细菌感染伤口和抗生素滥用已成为患者和医疗系统的重大负担。因此，迫切需要设计一种非抗生素依赖的多功能伤口敷料来治疗细菌感染的伤口。本研究以n -羧乙基壳聚糖（CEC）和端苯甲醛的Pluronic F127/碳纳米管（PF127/CNT）为材料，制备了一系列具有良好光热抗菌性能的导电自愈黏附纳米复合水凝胶，并在体内实验中证明了其作为感染创面光热治疗（PTT）药物的巨大潜力。该水凝胶具有适宜的凝胶时间、稳定的力学性能、止血性能、高吸水率和良好的生物降解性。负载抗生素盐酸莫西沙星后，水凝胶表现出ph响应释放特征和良好的抗菌活性。水凝胶具有良好的组织粘附性，在小鼠肝损伤模型、小鼠肝切口模型和小鼠截肢模型中均有良好的止血效果。CNTs的加入使水凝胶具有体外/体内光热抗菌活性和良好的导电性。小鼠全层皮肤创面感染模型的体内实验表明，水凝胶具有良好的治疗效果，可显著促进创面愈合、胶原沉积和血管生成。综上所述，这些导电光热自愈纳米复合水凝胶作为多功能伤口敷料，在治疗感染伤口方面显示出巨大的潜力。
Bacteria-infected wounds and antibiotics abuse have become significant burdens to patients and medical systems. Thus, designing a non-antibiotic-dependent multifunctional wound dressing for treating bacteria-infected wounds is urgently desired. Herein, a series of conductive self-healing and adhesive nanocomposite hydrogels with a remarkable photothermal antibacterial property based on N-carboxyethyl chitosan (CEC) and benzaldehyde-terminated Pluronic F127/carbon nanotubes (PF127/CNT) were developed, and their great potential as agents for photothermal therapy (PTT) of infected wounds was demonstrated in vivo. The hydrogels exhibited a suitable gelation time, stable mechanical properties, hemostatic properties, high water absorbency, and good biodegradability. After loading the antibiotic moxifloxacin hydrochloride, the hydrogels showed a pH-responsive release profile and good antibacterial activity. The tissue adhesive property of the hydrogels allowed them to have a good hemostatic effect in a mouse liver trauma model, mouse liver incision model, and mouse tale amputation model. The addition of CNTs endowed the hydrogel with in vitro/in vivo photothermal antimicrobial activity and good conductivity. An in vivo experiment in a mouse full-thickness skin wound-infected model indicated that the hydrogels had an excellent treatment effect leading to significantly enhanced wound closure healing, collagen deposition, and angiogenesis. In summary, these conductive photothermal self-healing nanocomposite hydrogels as multifunctional wound dressing exhibit great potential for the treatment of infected wounds.