Phyllodes tumor of the breast
Phyllodes tumor of the breast
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DOI：
10.1016/j.ijrobp.2007.06.059
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发表时间：
2008-02-01
影响因子：
7
通讯作者：
Ozsahin, Mahmut
中科院分区：
文献类型：
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作者：
Belkacemi, Yazid;Bousquet, Guilhem;Ozsahin, Mahmut
目的：为了更好地确定局部控制和生存的预后因素，以及不同的治疗选择的作用，叶状肿瘤，一种罕见的纤维上皮肿瘤的breast.Methods和材料：从1971年和2003年之间治疗的443名妇女的数据收集从罕见的癌症网络。中位年龄为40岁（范围：12-87岁）。良性肿瘤284例（64%），交界性肿瘤80例（18%），恶性肿瘤79例（18%）。手术包括保乳手术（BCS）377例（85%）和全乳切除术（TM）66例（15%）。结果：中位随访106个月后，局部复发率（LR）和远处转移率分别为19%和3.4%。在恶性和交界性组（n = 159）中，RT显著降低LR（p = 0.02），TM的结果优于BCS（p = 0.0019）。多变量分析显示，良性组织学、阴性切缘和初始治疗和RT后无残留病变（无RD）是局部控制的独立有利预后因素;良性组织学和低有丝分裂数是无病生存的独立有利预后因素;病理肿瘤大小
Purpose: To better identify prognostic factors for local control and survival, as well as the role of different therapeutic options, for phyllodes tumors, a rare fibroepithelial neoplasm of the breast.Methods and Materials: Data from 443 women treated between 1971 and 2003 were collected from the Rare Cancer Network. The median age was 40 years (range, 12-87 years). Tumors were benign in 284 cases (64%), borderline in 80 cases (18%), and malignant in 79 cases (18%). Surgery consisted of breast-conserving surgery (BCS) in 377 cases (85%) and total mastectomy (TM) in 66 cases (15%). Thirty-nine patients (9%) received adjuvant radiotherapy (RT).Results: After a median follow-up of 106 months, local recurrence (LR) and distant metastases rates were 19% and 3.4%, respectively. In the malignant and borderline group (n = 159), RT significantly decreased LR (p = 0.02), and TM had better results than BCS (p = 0.0019). Multivariate analysis revealed benign histology, negative margins, and no residual disease (no RD) after initial treatment and RT delivery as independent favorable prognostic factors for local control; benign histology and low number of mitosis for disease-free survival; and pathologic tumor size