Effect of exopolymers of Aureobasidium pullulans on improving osteoporosis induced in ovariectomized mice
Effect of exopolymers of Aureobasidium pullulans on improving osteoporosis induced in ovariectomized mice
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出芽短梗霉外聚合物对改善去势小鼠骨质疏松的作用
DOI：
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发表时间：
2006
影响因子：
2.8
通讯作者：
Huh Tae
中科院分区：
文献类型：
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作者：
Song Hebok;P. Chan;Dongsoo Min;Hwang Seung;Lee Won Kyu;Kang Heun;Park Bok;Jang Hee;Song Chang;Park Eui Kyun;Kim Shin;Huh Tae
用含有β-1，3/1，6-葡聚糖的出芽短梗霉SM-2001胞外聚合物抑制骨髓干细胞在与颅骨成骨细胞共培养系统中的破骨细胞形成。此外，该治疗还增加了成骨细胞中的矿物质沉积。这两个观察结果促使我们评估胞外聚合物是否可以用作抗骨质疏松剂，并在去卵巢的易患骨质疏松症的小鼠中将胞外聚合物防止骨丢失的效果与双膦酸阿伦磷酸酯进行了比较。给予去卵巢小鼠股骨重量和骨小梁体积(TBV)、骨小梁厚度(TBT)和皮质骨厚度(CBT)等组织形态计量学改变。综上所述，胞外聚合物治疗可抑制去卵巢所致的骨质疏松所致的骨质丢失，其效果与阿伦磷酸钠相当。
Treatment with exopolymers of Aureobasidium pullulans SM-2001 containing β-1,3/1,6-glucan inhibited osteoclastogenesis of bone marrow stem cells in a co-culture system with calvariae osteoblastic cells. In addition, the treatment increased mineral deposition in osteoblastic cells. These two observations prompted us to evaluate whether the exopolymers could be used as an anti-osteoporotic agent, and efficacy of the exopolymers to prevent bone loss was compared with alendronate, a bisphosphonate, in ovariectomized mice prone to osteoporosis. Administration of the exopolymers to the ovariectomized mice resulted in improved effects on femur weight and histomorphometric changes of femur such as trabecular bone volume (TBV), trabecular bone thickness (TBT), and cortical bone thickness (CBT). In conclusion, the exopolymers treatment inhibited bone loss from osteoporosis induced by ovariectomy, and the effect was comparable to alendronate administration.