EXPERIMENTAL STREPTOCOCCIC ENDOCARDITIS
EXPERIMENTAL STREPTOCOCCIC ENDOCARDITIS
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实验性链球菌性心内膜炎
DOI：
10.1001/archinte.1938.00180130068005
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发表时间：
1938
影响因子：
39
通讯作者：
R. Muether
中科院分区：
文献类型：
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作者：
R. A. Kinsella;R. Muether
I.通过静脉注射链球菌复制疾病细菌性心内膜炎的治疗仍然不成功的事实强调了理解这种疾病的困难。用血清和疫苗等免疫剂治疗这种疾病的彻底失败也表明，动物体内起作用的因素是独特的，而且大部分是未被识别的。一般来说，临床研究似乎确立了两个事实：第一，获得细菌性心内膜炎的患者总是先前遭受瓣膜组织的损伤，第二，细菌性心内膜炎是通过在该损伤的瓣膜中或其上植入细菌，通常是非溶血性链球菌，其通过诸如咽炎或中耳炎的局部感染的媒介进入血流。在某些情况下，不知道之前是否存在瓣膜损伤。它
I. REPRODUCTION OF THE DISEASE BY MEANS OF INTRAVENOUSLY INJECTED STREPTOCOCCI The fact that the treatment of bacterial endocarditis remains unsuccessful emphasizes the difficulty involved in understanding this disease. The utter failure to treat the disease successfully with such immunologic agents as serums and vaccines indicates also that the factors at work within the animal body are distinctive and for the most part unidentified. In a general way, two facts seem to be established by clinical studies: first, the patient who acquires bacterial endocarditis has invariably suffered previous injury to the tissues of the valves, and, second, bacterial endocarditis is established by the implantation in or on this injured valve of bacteria, usually nonhemolytic streptococci, which gain access to the blood stream through the medium of a local infection such as pharyngitis or otitis media. In some instances it is not known that previous injury to a valve existed. It