Risk of bipolar disorder and schizophrenia in relatives of people with attention-deficit hyperactivity disorder
Risk of bipolar disorder and schizophrenia in relatives of people with attention-deficit hyperactivity disorder
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DOI：
10.1192/bjp.bp.112.120808
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发表时间：
2013-08-01
影响因子：
10.5
通讯作者：
Landen, Mikael
中科院分区：
文献类型：
--
作者：
Larsson, Henrik;Ryden, Eleonore;Landen, Mikael
背景注意缺陷多动障碍（ADHD）与双相情感障碍和精神分裂症有关，双相情感障碍和ADHD的合并在病因学上不同于单纯的情感障碍。我们确定了61187名ADHD患者（先证者组）及其一级和二级亲属，并将他们与非ADHD患者及其相应亲属的对照组进行了匹配。条件Logistic回归被用来确定的风险，双相情感障碍和精神分裂症的亲属中的两个groups.ResultsFirst-degree亲属的ADHD先证者组的双相情感障碍（比值比（OR）= 1.84-2.54的父母，后代和全兄弟姐妹）和精神分裂症（OR = 1.71-2.22的父母，后代和全兄弟姐妹）的风险增加。双相情感障碍和精神分裂症的风险在第二度的亲属大大低于全siblings.ConclusionsThese研究结果表明，ADHD和双相情感障碍以及ADHD和精神分裂症的共同发生是由于共享的遗传因素，而不是代表完全病因学不同的子综合征。
BackgroundAttention-deficit hyperactivity disorder (ADHD) is associated with bipolar disorder and schizophrenia, and it has been suggested that combined bipolar disorder and ADHD is aetiologically distinct from the pure disorders.AimsTo clarify whether ADHD shares genetic and environmental factors with bipolar disorder and schizophrenia.MethodBy linking longitudinal Swedish national registers, we identified 61 187 persons with ADHD (the proband group) and their first- and second-degree relatives, and matched them with a control group of people without ADHD and their corresponding relatives. Conditional logistic regression was used to determine the risks of bipolar disorder and schizophrenia in the relatives of the two groups.ResultsFirst-degree relatives of the ADHD proband group were at increased risk of both bipolar disorder (odds ratio (OR) = 1.84-2.54 for parents, offspring and full siblings) and schizophrenia (OR = 1.71-2.22 for parents, offspring and full siblings). The risks of bipolar disorder and schizophrenia among second-degree relatives were substantially lower than among full siblings.ConclusionsThese findings suggest that the co-occurrence of ADHD and bipolar disorder as well as ADHD and schizophrenia is due to shared genetic factors, rather than representing completely aetiologically distinct subsyndromes.