Roxithromycin antagonizes catagen induction in murine and human hair follicles: implication of topical roxithromycin as hair restoration reagent
Roxithromycin antagonizes catagen induction in murine and human hair follicles: implication of topical roxithromycin as hair restoration reagent
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DOI：
10.1007/s00403-008-0899-1
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发表时间：
2009-06-01
影响因子：
3
通讯作者：
Hashizume, Hideo
中科院分区：
文献类型：
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作者：
Ito, Taisuke;Fukamizu, Hidekazu;Hashizume, Hideo
罗红霉素 (RXM) 是一种 14 元大环内酯类抗生素，具有多种生物调节功能，包括抗角质形成细胞凋亡活性。因此，RXM已被用于多种皮肤病的治疗。在这项研究中，人类和小鼠的毛囊接受了 RXM 治疗，以寻找治疗雄激素性脱发 (AGA) 等脱发疾病的可能性。在 AGA 中，二氢睾酮在易感个体的真皮乳头细胞中发出凋亡信号，在毛发生长初期提前终止并提前进入毛发生长中期。因此，抗凋亡药物有可能成为AGA新的候选药物。这项研究表明，RXM 在体外拮抗 IFN-γ 对小鼠和人类毛球角质形成细胞增殖和诱导细胞凋亡的抑制作用。 RXM 可增加毛发伸长并抑制体外 IFN-γ 在小鼠和人类毛囊中诱导的退行期样变化。此外，局部使用 5% RXM 溶液可有效恢复约一半 AGA 患者的毛发生长，且没有任何局部和全身副作用。因此，RXM是AGA毛发修复药物的新候选药物。
Roxithromycin (RXM) is a 14-member macrolide antibiotics, with a variety of bioregulatory functions including anti-apoptotic activity to keratinocytes. Therefore, RXM has been used for many kinds of skin diseases. In this study, human and murine hair follicles were treated with RXM in order to find the possibility to cure hair loss disease such as androgenetic alopecia (AGA). In AGA, dihydrotestosterone signals apoptosis in dermal papilla cells in susceptible individuals, resting in premature termination of anagen and early entry into catagen. Therefore, anti-apoptotitic drug has a possibility of new candidate for AGA. This study revealed RXM antagonized the in vitro inhibitory effect of IFN-gamma on proliferation of keratinocytes and induction of apoptosis in murine and human hair bulb. RXM increases hair elongation and inhibits catagen-like changes induced in vitro with IFN-gamma in murine and human hair follicles. Furthermore, topical 5% RXM solution effectively restores hair growth in about half of individuals with AGA without any local and systemic adverse effects. Therefore, RXM is new candidate as a hair restoration drug for AGA.