EFFECT OF HYPERTHERMIA, RADIATION AND ADRIAMYCIN COMBINATIONS ON TUMOR VASCULAR FUNCTION
EFFECT OF HYPERTHERMIA, RADIATION AND ADRIAMYCIN COMBINATIONS ON TUMOR VASCULAR FUNCTION
复制标题
DOI：
10.1016/0360-3016(82)90064-5
复制
发表时间：
1982-01-01
影响因子：
7
通讯作者：
CHMIELEWSKI, G
中科院分区：
文献类型：
--
作者：
EDDY, HA;CHMIELEWSKI, G
Pathophysiologic studies of tumor vascular responses to hyperthermia, radiation or adriamycin given alone or in specific combinations were made in the cervical carcinoma grown in the transport cheek pouch chamber of the Syrian hamster. A specially designed chamber containing a compartment for flowing water enabled controlled heating of the tumor and pouch to within 0.2.degree. C; the desired temperatures were achieved within 1 min. Heating at 42.degree. C for 30 min was followed, at 1, 5 or 24 h, by a 2nd heating for 30 min at 42.degree. C. In addition, the same period of heating was preceded or followed, at 1, 5, or 24 h intervals, by a single exposure to 2000 R or a single i.v. injection of adriamycin given at a rate of 0.45 mg/100 g body wt. Of the 3 modalities, heat appeared to have the greatest acute effect on the tumor vascular system. A single dose of heat produced a rapid but transient constriction followed by a prominent dilation of vessels. Two heating periods given at a 1 h interval caused persistent stasis in the tumor which progressed to coagulation necrosis. Although heating prior to irradiation or adriamycin, in general, increased the vascular responses to these agents, this sequence gave no tumor control. Radiation or adriamycin given prior to heating had relatively little effect on the vascular response to heating and produced no tumor control except when heat was applied shortly after irradiation. Changes in the microvasculature and perfusion in tumors, in response to hyperthermia alone or combined in specific sequences with radiation, can apparently alter the internal environment of the tumor to produce a greater degree of tumor control than can be attributed to direct cell killing by these agents.
