Associations of Serum Sclerostin and Polymorphisms in the SOST Gene With Bone Mineral Density and Markers of Bone Metabolism in Postmenopausal Chinese Women
Associations of Serum Sclerostin and Polymorphisms in the SOST Gene With Bone Mineral Density and Markers of Bone Metabolism in Postmenopausal Chinese Women
复制标题
中国绝经后女性血清硬化素和 SOST 基因多态性与骨密度和骨代谢标志物的关系。
DOI：
10.1210/jc.2013-2086
复制
发表时间：
2014-04-01
影响因子：
5.8
通讯作者：
Zhang, Zhenlin
中科院分区：
文献类型：
--
作者：
He, Jinwei;Zhang, Hao;Zhang, Zhenlin
目的
本研究旨在探讨绝经后妇女血清sclerostin水平与骨密度（BMD）及骨代谢指标之间的关系，以及sclerostin（SOST）基因单核苷酸多态性（SNPs）与血清sclerostin、BMD及骨代谢指标之间的关系。
设计
对703名绝经后中国妇女进行了横断面研究。对SOST基因的10个标签SNP（rs 1234612、rs 1513670、rs 1634330、rs 1708635、rs 2023794、rs7220711、rs74252774、rs 851057、rs 851058和rs 865429）进行基因分型。测定血清硬化素和骨代谢标志物，包括血清完整PTH、25-羟基维生素D [25（OH）D]、1型前胶原N端前肽和含交联C端肽（β-CTX）的I型胶原β-CrossLaps。采用双能X线骨密度仪测量腰椎和股骨近端骨密度。
结果
血清sclerostin与腰椎、股骨颈、全髋的BMD和血清25（OH）D呈正相关（均P <0.01），而与β-CTX呈负相关（P <0.01）。血清硬化素与BMD和血清β-CTX之间的显著相关性持续存在，即使在校正了年龄、体重指数和血清25（OH）D后也是如此（均P <0.01）。然而，血清硬化素与年龄或血清1型前胶原N-末端前肽之间没有相关性。我们未能确定SNP、SOST单倍型和BMD或血清硬化素之间的显著相关性。
结论
结果提示，血清硬化素与腰椎、股骨颈、全髋骨密度及血清25（OH）D呈正相关，与血清β-CTX呈负相关。SOST基因多态性可能不是中国绝经后妇女血清硬化素或骨密度变化的主要因素。
OBJECTIVE
The aims of this study were as follows: 1) to evaluate the association of serum sclerostin with bone mineral density (BMD) and markers of bone metabolism in postmenopausal Chinese women and 2) to observe the relationships of single-nucleotide polymorphisms (SNPs) within the sclerostin (SOST) gene with serum sclerostin, BMD, and markers of bone metabolism.
DESIGN
A cross-sectional study was conducted with 703 postmenopausal Chinese women. Ten tagging SNPs (rs1234612, rs1513670, rs1634330, rs1708635, rs2023794, rs7220711, rs74252774, rs851057, rs851058, and rs865429) of the SOST gene were genotyped. Serum sclerostin and markers of bone metabolism were measured, including serum intact PTH, 25-hydroxyvitamin D [25(OH)D], procollagen type 1 N-terminal propeptide, and β-CrossLaps of type I collagen containing cross-linked C-telopeptide (β-CTX). The BMD of the lumbar spine and proximal femur were measured by dual-energy X-ray absorptiometry.
RESULTS
Serum sclerostin was positively correlated with BMD at the lumbar spine, femoral neck, and total hip and with serum 25(OH)D (all P < .01) but negatively correlated with β-CTX (P < .01). The significant relationships between serum sclerostin and BMD and with serum β-CTX persisted, even after adjustments for age, body mass index, and serum 25(OH)D (all P < .01). However, there was no correlation between serum sclerostin and age or serum procollagen type 1 N-terminal propeptide. We failed to identify a significant association between the SNP, haplotypes of SOST and BMD, or serum sclerostin.
CONCLUSION
Our results suggested that serum sclerostin was positively correlated with the BMD at the lumbar spine, femoral neck, and total hip and with serum 25(OH)D but was negatively correlated with serum β-CTX. Genetic polymorphisms of SOST may not be a major contributor to variations in the serum sclerostin or BMD in postmenopausal Chinese women.