EFFECT OF ALDOSTERONE ON METABOLISM OF MAGNESIUM
EFFECT OF ALDOSTERONE ON METABOLISM OF MAGNESIUM
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DOI：
10.1210/jcem-22-12-1187
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发表时间：
1962-01-01
影响因子：
5.8
通讯作者：
BIGLIERI, EG
中科院分区：
文献类型：
--
作者：
HORTON, R;BIGLIERI, EG
对5例原发性醛固酮增多症患者和1例肾上腺切除患者的镁代谢与钾代谢进行了比较。在原发性醛固酮增多症中，尿镁排泄和清除增加，尽管血清镁是正常的。快速输注等渗盐水导致钾和镁的排泄显著增加，可能反映了滤过负荷增加。手术切除肾上腺腺瘤后，尿钾和镁同时减少，并持续数周。螺内酯可降低2例原发性醛固酮增多症患者的尿镁。肾上腺切除患者肌肉注射400 μ g d-醛固酮后尿钾和镁的增加可被螺内酯逆转。这些研究表明，醛固酮以平行的方式增加镁和钾的清除和排泄。
The metabolism of magnesium was compared with that of potassium in 5 patients with primary aldosteronism and in an adrenalectomized subject. In primary aldosteronism the urinary excretion and clearance of magnesium is increased although the serum magnesium is normal. A rapid infusion of isotonic saline resulted in a markedly increased excretion of both potassium and magnesium, probably reflecting an increased filtered load. After the surgical removal of adrenal adenomata there was a simultaneous decrease in both the urinary potassium and magnesium, which continued for several weeks after surgery. Spironolactone reduced the urinary magnesium in 2 patients with primary aldosteronism. The increase in both urinary potassium and magnesium after the administration of 400 ug d-aldosterone intramuscularly in an adrenalectomized patient was reversed by spironolactone. These studies suggest that aldosterone increases the clearance and excretion of magnesium and potassium in a parallel manner.