Proinflammatory cytokines and leptin are increased in serum of prepubertal obese children.
Proinflammatory cytokines and leptin are increased in serum of prepubertal obese children.
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DOI：
10.1155/mi.2005.180
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发表时间：
2005-08-14
影响因子：
4.6
通讯作者：
Sen Y
中科院分区：
文献类型：
--
作者：
Aygun AD;Gungor S;Ustundag B;Gurgoze MK;Sen Y
在青春期前儿童中，细胞因子、瘦素和体重以及肥胖参数是如何相互关联的尚未得到证实。本研究的目的是探讨循环中某些细胞因子水平与瘦素和体重指数的关系。在男女肥胖儿童中进行病例对照研究。肥胖组由63名青春期前的儿童组成，对照组由相同数量的按年龄和性别配对的非肥胖儿童组成。肥胖儿童的平均血清瘦素浓度为19.9 ± 7.4 ng/mL，显著高于对照组（7.9 ± 5.1 ng/mL）。肥胖组的血清IL-1β、IL-6和TNF-α水平也显著高于对照组（分别为33.0 ± 8.9、45.2 ± 11.8和9.2 ± 2.3 pg/mL vs 3.6 ± 1.0、13.1 ± 3.9和3.9 ± 1.0 pg/mL）。有争议的是，肥胖组的血清IL-2水平降低为0.4 ± 0.1 U/L，而肥胖组为0.9 ± 0.1 U/L。肥胖可能是一种低度全身性炎症性疾病。肥胖的青春期前儿童血清中IL-1β、IL-6和TNF-α水平升高，这些都是炎症的标志物。
It has not yet been shown in prepubertal children how cytokines, leptin, and body mass, as well as parameters of obesity are interrelated. The aim of this study was to explore the relation between circulating levels of some cytokines with leptin and body mass index. A case control study was carried out in obese children of both sexes. An obese group was carried out with 63 school prepubertal children and a control group comprised the same number of nonobese children paired by age and by sex. Mean serum leptin concentration was significantly higher in the obese children at 19.9 ± 7.4 ng/mL, than the control group (7.9 ± 5.1 ng/mL). Serum IL-1β, IL-6, and TNF-α levels were also significantly higher in the obese group than controls (33.0 ± 8.9, 45.2 ± 11.8, and 9.2 ± 2.3 pg/mL, versus 3.6 ± 1.0, 13.1 ± 3.9, and 3.9 ± 1.0 pg/mL, resp). In controversy, serum IL-2 level was diminished in the obese group as 0.4 ± 0.1 versus 0.9 ± 0.1 U/L. Obesity may be a low-grade systemic inflammatory disease. Obese prepubertal children have elevated serum levels of IL-1β, IL-6, and TNF-α which are known as markers of inflammation.