Relation of Neutrophil/Lymphocyte Ratio to Coronary Flow to In-Hospital Major Adverse Cardiac Events in Patients With ST-Elevated Myocardial Infarction Undergoing Primary Coronary Intervention
Relation of Neutrophil/Lymphocyte Ratio to Coronary Flow to In-Hospital Major Adverse Cardiac Events in Patients With ST-Elevated Myocardial Infarction Undergoing Primary Coronary Intervention
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DOI：
10.1016/j.amjcard.2012.04.041
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发表时间：
2012-09-01
影响因子：
2.8
通讯作者：
Gibson, Charles Michael
中科院分区：
文献类型：
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作者：
Akpek, Mahmut;Kaya, Mehmet Gungor;Gibson, Charles Michael
随着对炎症在动脉粥样硬化性疾病患者中作用的认识不断加深，研究集中在高敏C反应蛋白（hs-CRP）和其他炎症标志物与ST段抬高心肌梗死结局的相关性上。本研究的目的是探讨中性粒细胞/淋巴细胞（N/L）比值与接受直接经皮冠状动脉介入治疗（PCI）的ST段抬高型心肌梗死患者的院内主要不良心脏事件（MACE）之间的关系。在418例连续接受PCI的原发性患者中评估了入院时hs-CRP和N/L比值与PCI后心肌梗死溶栓（TIMI）血流分级的相关性。无复流组（TIMI 0/1/2级血流，n = 158）的N/L比值显著高于正常血流组（TIMI 3级血流，n = 260，4.6 ± 1.7 vs 3.1 ± 1.9，p
With the growing understanding of the role of inflammation in patients with atherosclerotic disease, studies have focused on high-sensitivity C-reactive protein (hs-CRP) and other inflammatory markers in their association with outcomes in ST-segment elevation myocardial infarction. The goal of this study was to investigate the association of the neutrophil/lymphocyte (N/L) ratio and in-hospital major adverse cardiac events (MACEs) in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention (PCI). The association of hs-CRP and N/L ratio on admission with Thrombolysis In Myocardial Infarction (TIMI) flow grade after PCI was assessed in 418 consecutive primary patients with PCI. The N/L ratio was significantly higher in the no-reflow group (TIMI grade 0/1/2 flow, n = 158) compared to that of the normal-flow group (TIMI grade 3 flow, n = 260, 4.6 +/- 1.7 vs 3.1 +/- 1.9, p