SEX LINKAGE, SEX-SPECIFIC SELECTION, AND THE ROLE OF RECOMBINATION IN THE EVOLUTION OF SEXUALLY DIMORPHIC GENE EXPRESSION
SEX LINKAGE, SEX-SPECIFIC SELECTION, AND THE ROLE OF RECOMBINATION IN THE EVOLUTION OF SEXUALLY DIMORPHIC GENE EXPRESSION
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DOI：
10.1111/j.1558-5646.2010.01136.x
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发表时间：
2010-12-01
期刊：
影响因子：
3.3
通讯作者：
Clark, Andrew G.
中科院分区：
文献类型：
--
作者：
Connallon, Tim;Clark, Andrew G.
性别偏见基因--在雄性和雌性体内差异表达的基因--在动物基因组中非随机分布，性染色体和常染色体通常携带明显不同浓度的雄性和雌性偏见基因。这些连锁模式通常依赖于基因和血统，在功能遗传类别和物种之间有所不同。尽管性别特异性选择通常被假设为塑造性别连锁和常染色体基因内容的进化，但群体遗传学理论尚未解释从经验文献中涌现的许多基因和血统特异性。为了改善进化理论与快速增长的全基因组实证研究之间的联系，我们通过开发和分析一个生物信息模型来扩展先前的性别特异性选择的群体遗传学理论，该模型包含了性别连锁、多效性、重组和上位性，这些因素可能在基因和物种之间有所不同。我们的结果表明，性别特异性选择和性别特异性重组率可以产生并与基因组学文献中报告的基因和物种特异性连锁模式兼容。该理论表明，性别选择可能强烈地影响动物基因组的结构，以及潜在的性二型特征的固定替换的染色体分布。
Sex-biased genes-genes that are differentially expressed within males and females-are nonrandomly distributed across animal genomes, with sex chromosomes and autosomes often carrying markedly different concentrations of male- and female-biased genes. These linkage patterns are often gene- and lineage-dependent, differing between functional genetic categories and between species. Although sex-specific selection is often hypothesized to shape the evolution of sex-linked and autosomal gene content, population genetics theory has yet to account for many of the gene- and lineage-specific idiosyncrasies emerging from the empirical literature. With the goal of improving the connection between evolutionary theory and a rapidly growing body of genome-wide empirical studies, we extend previous population genetics theory of sex-specific selection by developing and analyzing a biologically informed model that incorporates sex linkage, pleiotropy, recombination, and epistasis, factors that are likely to vary between genes and between species. Our results demonstrate that sex-specific selection and sex-specific recombination rates can generate, and are compatible with, the gene- and species-specific linkage patterns reported in the genomics literature. The theory suggests that sexual selection may strongly influence the architectures of animal genomes, as well as the chromosomal distribution of fixed substitutions underlying sexually dimorphic traits.