Structural and mechanical basis of exercise-induced muscle injury.
Structural and mechanical basis of exercise-induced muscle injury.
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DOI：
10.1249/00005768-199205000-00005
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发表时间：
1992-05
影响因子：
4.1
通讯作者：
J. Fridén;J. Fridén;R. Lieber;R. Lieber
中科院分区：
文献类型：
--
作者：
J. Fridén;J. Fridén;R. Lieber;R. Lieber
在动物和人类的研究中都有充分的证据表明，不习惯的肌肉运动，特别是古怪的肌肉运动，可能会导致肌肉纤维收缩和细胞骨架成分的损伤。这些损伤通常包括：Z波段流动和溶解，A波段破裂，中间丝系统的解体，以及肌原纤维的错位。这种损伤的力学基础被认为是由于纤维的应变值，而不是施加在纤维上的绝对应力。我们假设偏心收缩引起的损伤发生在治疗期的早期，即在最初的几分钟内。结构异常在快速抽动糖酵解纤维中占主导地位。在本文的最后部分，我们假设了一种基于肌肉纤维氧化能力作为决定因素的损伤方案。
It is well documented in both animal and human studies that unaccustomed, particularly eccentric, muscle exercise may cause damage of muscle fiber contractile and cytoskeletal components. These injuries typically include: Z-band streaming and dissolution, A-band disruption, disintegration of the intermediate filament system, and misalignment of the myofibrils. The mechanical basis for this damage is suggested to be due to the fiber strain magnitude rather than the absolute stress imposed on the fiber. We hypothesize that eccentric contraction-induced damage occurs early in the treatment period, i.e., within the first few minutes. The structural abnormalities predominate in the fast-twitch glycolytic fibers. In the final section of this paper, we hypothesize a damage scheme, based on the muscle fiber oxidative capacity as a determining factor.