Neural circuitry underlying the interaction between emotion and asthma symptom exacerbation
Neural circuitry underlying the interaction between emotion and asthma symptom exacerbation
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DOI：
10.1073/pnas.0504365102
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发表时间：
2005-09-13
影响因子：
11.1
通讯作者：
Davidson, RJ
中科院分区：
文献类型：
--
作者：
Rosenkranz, MA;Busse, WW;Davidson, RJ
与许多炎症性疾病一样，哮喘也受到心理应激的影响，这表明调节炎症的外周因子与情绪和应激反应的中枢神经回路之间可能发生相互调节。尽管有人认为情绪因素可能会调节哮喘的炎症过程，相反，外周炎症信号会影响大脑，但涉及的神经回路仍然难以捉摸。在这里，我们显示，使用功能性磁共振成像，在前扣带皮层和哮喘相关的情绪活动，与价中性刺激相比，与哮喘受试者暴露于抗原的炎症和气道阻塞的标志物。这种激活占外周标记物变异的>= 40%，提示哮喘气道疾病情绪诱导调节的神经基础。前扣带皮层和前扣带皮层与感觉刺激的情感评价、稳态反应的调节和内脏感知有关。在患有哮喘和其他压力相关疾病的个体中，这些大脑区域可能对疾病特异性情绪和传入生理信号反应过度，这可能导致外周过程的失调，例如炎症。
Asthma, like many inflammatory disorders, is affected by psychological stress, suggesting that reciprocal modulation may occur between peripheral factors regulating inflammation and central neural circuitry underlying emotion and stress reactivity. Despite suggestions that emotional factors may modulate processes of inflammation in asthma and, conversely, that peripheral inflammatory signals influence the brain, the neural circuitry involved remains elusive. Here we show, using functional magnetic resonance imaging, that activity in the anterior cingulate cortex and insula to asthma-relevant emotional, compared with valence-neutral stimuli, is associated with markers of inflammation and airway obstruction in asthmatic subjects exposed to antigen. This activation accounts for >= 40% of the variance in the peripheral markers and suggests a neural basis for emotion-induced modulation of airway disease in asthma. The anterior cingulate cortex and insula have been implicated in the affective evaluation of sensory stimulation, regulation of homeostatic responses, and visceral perception. In individuals with asthma and other stress related conditions, these brain regions may be hyperresponsive to disease-specific emotional and afferent physiological signals, which may contribute to the dysregulation of peripheral processes, such as inflammation.