Quantitative ultrasound predicts hip and non-spine fracture in men: the MrOS study
Quantitative ultrasound predicts hip and non-spine fracture in men: the MrOS study
复制标题
DOI：
10.1007/s00198-006-0317-5
复制
发表时间：
2007-06-01
影响因子：
4
通讯作者：
Orwoll, E. S.
中科院分区：
文献类型：
--
作者：
Bauer, D. C.;Ewing, S. K.;Orwoll, E. S.
定量超声（QUS）与女性骨折风险相关，但在男性中的数据很少。我们研究了5,607名老年男性，发现QUS预测髋部和任何非脊柱骨折的风险几乎与BMD一样。QUS和BMD的联合测量并不优于单独测量的上级指标。归纳定量超声（QUS）预测老年女性骨折风险，但很少有老年男性的前瞻性研究。我们研究了QUS和BMD测量预测髋关节和其他非脊柱骨折的能力，在一项以人群为基础的老年男性study.Methods跟骨QUS和髋关节BMD测量5,607名男性年龄>= 65岁，从美国6个中心招募。在基线时，重复QUS测量并重新定位，随后通过审查X线片或X线片报告记录髋关节和其他非脊柱骨折。QUS和骨折之间的关系进行了检查，比例风险模型调整的年龄和临床。我们使用受试者操作特征曲线和预测骨折风险模型来确定单独QUS、单独BMD或QUS+BMD组合的效用。结果在平均4.2年的随访期间（99%完成随访），239名男性患有非脊柱骨折，其中包括49例髋部骨折。宽带超声衰减（BUA）的每个标准差降低与髋关节（相对危险度=2.0，CI：1.5，2.8）和任何非脊柱骨折（相对危险度=1.6，CI：1.4，1.8）的风险增加相关。BUA单独、BMD单独和BUA+BMD组合的受试者工作特征曲线下面积和预测骨折概率相似，表明一旦BUA或BMD已知，其他测量不会增加有用的信息。其他QUS参数给出了类似的results.Conclusions QUS测量预测的风险髋关节和任何非脊柱骨折的老年男性，这样做几乎以及髋关节BMD测量。QUS和BMD的联合测量并不优于单独测量的上级。
Quantitative ultrasound (QUS) is associated with fracture risk in women, but there are few data in men. We studied 5,607 older men and found that QUS predicts hip and any non-spine fracture risk nearly as well as BMD. Combined measurements of QUS and BMD are not superior to either measurement alone.Indroduction Quantitative ultrasound (QUS) predicts fracture risk among older women, but there are few prospective studies among older men. We studied the ability of QUS and BMD measurements to predict hip and other non-spine fractures in a population-based study of older men.Methods Calcaneal QUS and hip BMD were measured in 5,607 men aged >= 65 years recruited from six US centers. At baseline duplicate QUS measurements with repositioning were obtained, and subsequent hip and other non-spine fractures were documented by review of x-rays or x-ray reports. The relationships between QUS and fractures were examined with proportional hazard models adjusted for age and clinic. We used receiver operating characteristic curves and predicted fracture risk models to determine the utility of QUS alone, BMD alone or the combination of QUS+BMD.Results During a mean follow-up of 4.2 years with 99% complete follow-up, 239 men suffered a non-spine fracture, including 49 hip fractures. Each standard deviation reduction in broadband ultrasonic attenuation (BUA) was associated with an increased risk of hip (relative hazard=2.0, CI: 1.5, 2.8) and any non-spine fracture (relative hazard=1.6, CI: 1.4, 1.8). The area under the receiver operating characteristic curve and the predicted probability of fracture were similar for BUA alone, BMD alone and the combination of BUA+BMD, indicating that once BUA or BMD is known, the other measurement does not add useful information. Other QUS parameters gave similar results.Conclusions QUS measurements predict the risk of hip and any non-spine fracture in older men, and do so nearly as well as hip BMD measurements. Combined measurements of QUS and BMD are not superior to either measurement alone.