Tetraploid complementation proves pluripotency of induced pluripotent stem cells derived from adipose tissue
Tetraploid complementation proves pluripotency of induced pluripotent stem cells derived from adipose tissue
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DOI：
10.1111/cpr.12152
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发表时间：
2015-02
影响因子：
8.5
通讯作者：
Chenchen Zhou;Xiaoxiao Cai;Y. Fu;Xue-Qin Wei;Na Fu;Jiamin Xie;Yunfeng Lin
中科院分区：
文献类型：
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作者：
Chenchen Zhou;Xiaoxiao Cai;Y. Fu;Xue-Qin Wei;Na Fu;Jiamin Xie;Yunfeng Lin
最近，在四倍体互补分析中，诱导多能干细胞(IPS)在产生成年小鼠后显示出多能性。这些研究将我们引向了将体细胞重新编程为全多能细胞的最后一块拼图，这些细胞在大多数应用中起着胚胎干细胞的作用。然而，在之前的所有研究中，皮肤成纤维细胞被用作重新编程的起始群体，这引发了iPS细胞的多能性是否依赖于特定的起始细胞类型的问题。
Recently, pluripotency of induced pluripotent stem (iPS) cells has been displayed after producing adult mice, in tetraploid complementation assays. These studies lead us to the last piece of the puzzle for reprogramming somatic cells into fully pluripotent cells which function as embryonic stem cells in most applications. However, in all of previous studies, skin fibroblasts were used as the starting population for reprogramming, raising questions as to whether the pluripotency of the iPS cells was dependent on the particular starting cell type.