Distinction between color photoreceptor cell fates is controlled by prospero in Drosophila
Distinction between color photoreceptor cell fates is controlled by prospero in Drosophila
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DOI：
10.1016/s1534-5807(03)00156-4
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发表时间：
2003-06-01
影响因子：
11.8
通讯作者：
Desplan, C
中科院分区：
文献类型：
--
作者：
Cook, T;Pichaud, F;Desplan, C
果蝇复眼由大约750个独立功能的小眼组成，每个小眼包含两个感光细胞亚群。外部光感受器参与运动检测，而内部光感受器有助于色觉。虽然内部光感受器R7和R8最终分化为功能相关的细胞，但它们在分子和形态组成上不同。我们的数据表明，R7与R8细胞命运决定的几个方面是由转录因子Prospero（Pros）调节的。具体表现在。R7细胞，和R7细胞突变体的前抑制; R8视紫红质，失去R7视紫红质，并获得R8样形态。这表明，R7内感光细胞的命运是从默认的R8样的命运，这是调节，部分，通过R7细胞中的R8视紫红质的直接转录抑制。此外，这项研究为pros提供了转录靶点，可能有助于了解其在调节果蝇和脊椎动物神经元发育中的作用。
The Drosophila compound eye consists of similar to750 independently functioning ommatidia, each containing two photoreceptor subpopulations. The outer photoreceptors participate in motion detection, while the inner photoreceptors contribute to color vision. Although the inner photoreceptors, R7 and R8, terminally differentiate into functionally related cells, they differ in their molecular and morphological makeup. Our data indicates that several aspects of R7 versus R8 cell fate determination are regulated by the transcription factor Prospero (Pros). pros is specifically expressed in. R7 cells, and R7 cells mutant for pros derepress; R8 rhodopsins, lose R7 rhodopsins and acquire an R8-like morphology. This suggests that R7 inner photoreceptor cell fate is acquired from a default R8-like fate that is regulated, in part, via the direct transcriptional repression of R8 rhodopsins in R7 cells. Furthermore, this study provides transcriptional targets for pros that may lend insight into its role in regulating neuronal development in flies and vertebrates.