SEX-DIFFERENCES IN SERUM LEVELS OF N-ACETYL-BETA-HEXOSAMINIDASE IN INFANCY - CORRELATION OF ENZYME-ACTIVITY WITH TESTOSTERONE LEVELS
SEX-DIFFERENCES IN SERUM LEVELS OF N-ACETYL-BETA-HEXOSAMINIDASE IN INFANCY - CORRELATION OF ENZYME-ACTIVITY WITH TESTOSTERONE LEVELS
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DOI：
10.1016/0378-3782(80)90035-3
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发表时间：
1980-01-01
影响因子：
2.5
通讯作者：
KOLDOVSKY, O
中科院分区：
文献类型：
--
作者：
OBERKOTTER, LV;TENORE, A;KOLDOVSKY, O
婴儿血清N-乙酰-β-氨基己糖苷酶(HEX)活性水平呈现性别二型性。男性的总HEX活性[M]在1到3个月之间。年龄显著高于女性[F]水平，(男性，1535。+-)。每毫升300nmol/60min；F，1150±-。P<；0.0005)，而A(不稳定)同工酶在总活性中所占的比例明显较低(M，56.0.+-)。4.2，不是。=24；女性，64.3。+-。4.6，不。=21，P<；0.0005)。这些发现导致了对血清中睾酮浓度和HEX活性之间的关系的研究。样品来自M(No.=36)和F(No.=33)1至6个月的婴儿。年龄也包括在内。无论男女，睾酮与总HEX(M，r=0.71；F，r=0.73)、HEX A(M，r=0.68；F，r=0.56)和HEX B(M，r=0.68；F，r=0.72)均呈高度相关(P<；0.0005)。睾酮水平与%A：M，r=-0.56；F，r=-0.38(P<；分别为0.0025和0.025)呈负相关。在男性和女性成人中，HEX水平和睾酮之间没有明显的相关性(r分别为0.20和0.18)。这些数据表明，在人类发育的最初几个月，睾丸激素参与了HEX活动的调节。
Serum levels of N-acetyl-.beta.-hexosaminidase (HEX) activity in infants display a sexual dimorphism. Total HEX activity in males [M] between 1 and 3 mo. of age is significantly elevated over female [F] levels, (M, 1535 .+-. 300 nmol/60 min per ml; F, 1150 .+-. 203, P < 0.0005), and the A (labile) isozyme constitutes a significantly lower proportion of the total activity present (M, 56.0 .+-. 4.2, no. = 24; F, 64.3 .+-. 4.6, no. = 21, P < 0.0005). These findings led to an investigation of the relationship between testosterone concentration and HEX activity in serum. Samples from M (no. = 36) and F (no. = 33) infants between 1 and 6 mo. of age were included. In both sexes, a high degree of correlation (P < 0.0005) was observed between testosterone and total HEX (M, r = 0.71; F, r = 0.73), HEX A (M, r = 0.68; F, r = 0.56) and HEX B (M, r = 0.68; F, r = 0.72). An inverse relationship exists between testosterone levels and % A: M, r = -0.56; F, r = -0.38 (P < 0.0025 and 0.025, respectively). No correlation between HEX levels and testosterone was evident in either male or female adults (r = 0.20 and 0.18, respectively). The data implicate testosterone in the regulation of HEX activity during the early months of human development.