Photoadaptation of vitiliginous skin to targeted ultraviolet B phototherapy.
Photoadaptation of vitiliginous skin to targeted ultraviolet B phototherapy.
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白癜风皮肤对定向紫外线 B 光疗的光适应。
DOI：
10.1111/j.1600-0781.2007.00311.x
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Hamzavi,Iltefat
中科院分区：
文献类型：
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作者：
Rivard,Jennifer;Hexsel,Camile;Owen,Michael;Strickland,FaithM;Lim,HenryW;Hamzavi,Iltefat
背景：由于光适应，白癜风患者可以耐受增加剂量的紫外线（UV）辐射。在这项试验性研究中，5例菲茨帕特里克皮肤光型IV-VI白癜风患者接受了6次有针对性的UVB光疗治疗，治疗时间为3-week period.Methods：为了研究光适应，在治疗和未治疗的白癜风和正常皮肤上进行最小红斑剂量（MED）测试，基线和治疗3次和6次后。结果：白癜风患者治疗前后平均MED变化率为0%~ 128%，平均为48.8%。结论：本研究的初步阶段提示部分白癜风患者可能对靶向UVB光疗产生了光适应。
Background:Increasing doses of ultraviolet (UV) radiation are tolerated in patients with vitiligo, due to photoadaptation. In this pilot study, five patients with Fitzpatrick skin phototypes IV–VI with vitiligo received six treatments of targeted UVB phototherapy over a 3‐week period.Methods:To investigate photoadaptation, minimal erythema dose (MED) testing was conducted on treated and untreated vitiliginous and normal skin at baseline and after three and six treatments. One patient had unattainable MED values, and was hence excluded.Results:Percent change in MED from before to after all treatments in vitiliginous skin ranged from 0% to 128%, with a mean of 48.8%.Conclusion:The pilot phase of this study suggests possible photoadaptation of vitiliginous skin of some patients to targeted UVB phototherapy.