Design and development of a suitable adsorbent to capture theophylline for non-invasive therapeutic drug monitoring with exhaled breath
Design and development of a suitable adsorbent to capture theophylline for non-invasive therapeutic drug monitoring with exhaled breath
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设计和开发合适的吸附剂来捕获茶碱，用于呼出气的非侵入性治疗药物监测
DOI：
10.1039/c4ay02243b
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发表时间：
2015
影响因子：
3.1
通讯作者：
Tsutomu Kawabe
中科院分区：
文献类型：
--
作者：
Atsushi Yamamoto;Sayaka Hioki;Chihiro Tanada;Toshio Miwa;Yoshinori Inoue;Ryohei Yamamoto;Miyoko Matsushima;Tsutomu Kawabe
探讨了呼气在治疗药物监测领域中替代血液/血浆的可能性。以茶碱作为非挥发性药物的模型化合物，研究了适合于从呼气中捕获药物的吸附剂。采用悬浮共聚法制备了两种不同单体组成的大孔吸附材料。通过气溶胶生成和老鼠呼出来评价合成的吸附剂和两种传统气体吸附剂的捕集性能。药物捕获效率并没有通过减小孔径和增加比表面积来提高。研究发现，在吸附剂表面吸附气溶胶颗粒需要一个亲水区，但茶碱的吸附也需要一个疏水区。将该材料应用于大鼠静脉推注实验。呼气中茶碱的浓度范围为0~0.02ngmin−1，与血液中茶碱浓度的变化相似，其范围为0~37μg m L−1。
The possibility of using exhaled breath as a substitute for blood/plasma in areas of therapeutic drug monitoring was investigated. Theophylline was used as a model chemical of non-volatile drugs and the adsorbents suitable for drug capture from exhaled breath were studied. Two macro-porous adsorbents with different monomer compositions were prepared by suspension copolymerization. The capture properties of the synthesized adsorbents and two conventional gas adsorbents packed in a cartridge were evaluated by both aerosol generation and rat expiration. The efficiency of drug capture did not improve by decreasing the pore size and by increasing the specific surface area. A hydrophilic region was found to be necessary for holding the aerosol particles on the adsorbent surface, but a hydrophobic region is also necessary for the adsorption of theophylline. The materials were applied to the intravenous bolus experiment of rats. The amount of theophylline collected from exhaled breath was in the range of 0–0.02 ng min−1, and it varied similarly to the concentration in blood, which was in the range of 0–37 μg mL−1.