Motile-Cilia-Mediated Flow Improves Sensitivity and Temporal Resolution of Olfactory Computations
Motile-Cilia-Mediated Flow Improves Sensitivity and Temporal Resolution of Olfactory Computations
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DOI：
10.1016/j.cub.2016.11.036
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发表时间：
2017-01-23
期刊：
影响因子：
9.2
通讯作者：
Jurisch-Yaksi, Nathalie
中科院分区：
文献类型：
--
作者：
Reiten, Ingrid;Uslu, Fazil Emre;Jurisch-Yaksi, Nathalie
运动纤毛是覆盖多个上皮细胞表面的活跃跳动的毛发状结构。纤毛跳动产生的流动用于各种功能，并取决于纤毛的空间位置和生物物理特性。在这里，我们表明，在水生脊椎动物的鼻子的能动纤毛空间组织和稳定跳动的不对称模式，导致在鼻子周围的强大和刻板的流动。我们的研究结果表明，这些流场吸引气味的鼻坑，并促进检测气味的嗅觉系统在停滞的环境。此外，我们表明，纤毛跳动迅速交换的内容的鼻子，从而提高了时间分辨率的嗅觉系统检测动态变化的气味羽流在湍流环境中。总之，我们的工作揭示了纤毛跳动产生流场的核心功能，增加了脊椎动物大脑中嗅觉计算的灵敏度和时间分辨率。
Motile cilia are actively beating hair-like structures that cover the surface of multiple epithelia. The flow that ciliary beating generates is utilized for diverse functions and depends on the spatial location and biophysical properties of cilia. Here we show that the motile cilia in the nose of aquatic vertebrates are spatially organized and stably beat with an asymmetric pattern, resulting in a robust and stereotypical flow around the nose. Our results demonstrate that these flow fields attract odors to the nose pit and facilitate detection of odors by the olfactory system in stagnant environments. Moreover, we show that ciliary beating quickly exchanges the content of the nose, thereby improving the temporal resolution of the olfactory system for detecting dynamic changes of odor plumes in turbulent environments. Altogether, our work unravels a central function of ciliary beating for generating flow fields that increase the sensitivity and the temporal resolution of olfactory computations in the vertebrate brain.